Genetic basis of tobacco dependence

被引：3

作者：

Barrueco, M

Alonso, A

González-Sarmiento, R

机构：

[1] Univ Salamanca, Fac Med, Dept Med, Unidad Med Mol, E-37008 Salamanca, Spain

[2] Hosp Univ Salamanca, Serv Neumol, Salamanca, Spain

[3] Unidad Docente Med Familiar & Comunitaria Salaman, Salamanca, Spain

[4] Inst Neurociencias Castilla & Leon, Salamanca, Spain

来源：

MEDICINA CLINICA | 2005年 / 124卷 / 06期

关键词：

smoking; genes; polymorphism;

D O I：

10.1157/13071764

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dependence on tobacco is one of the most important health problems in our society due to the direct relationship with lung cancer. Early studies in twins revealed that genetic factors modify the susceptibility to develop tobacco dependence. Different studies are underway to try to find an association between polymorphisms of genes involved either in nicotine metabolization or in neural transmission and the initiation and maintenance of the dependece on tobacco. Here we review the studies performed so far and discuss new persepctives for future studies.

引用

页码：223 / 228

页数：6

共 84 条

[1] Nitric oxide mediates mecamylamine- and naloxone-precipitated nicotine withdrawal [J].