Fine needle aspiration cytology in recurrent amelanotic melanoma - A case report

被引:6
作者
Siddaraju, Neelaiah [1 ]
Yaranal, Parasappa J. [1 ]
Mishra, Manisha Manaswini [1 ]
Soundararaghavan, Jayanthi [1 ]
机构
[1] Jawharlal Inst Postgrad Med Educ & Res, Dept Pathol, Pondicherry 605006, India
关键词
melanoma; amelanotic; local neoplasm recurrence; immunohistochemistry; aspiration biopsy; fine-needle;
D O I
10.1159/000325851
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Background Amelanotic melanoma can mimic a wide variety of epithelial and nonepithelial, malignant tumors. Varied cytomorphology of melanoma has been described on exfoliative and fine needle aspiration cytology (FNAC). We report a case of recurrent amelanotic melanoma to highlight its varied cytomorphologic features, which may cause diagnostic problems on cytologic and on histologic examinations. Case A 63-year-old male presented with nodular swellings in the right anterior chest wall, right axilla and back. A nodule in the chest had been excised 6 months earlier. Clinically, the lesion was interpreted as recurrent soft tissue sarcoma. FNAC revealed malignant cells with highly varied morphology with plasmacytoid and pleomorphic malignant cells with occasional fibrocollagenous tissue strands showing adherent neoplastic cells. A cytologic diagnosis of pleomorpbic malignant tumor was suggested, and the original histologic slides were reviewed; they showed a striking alveolar pattern that vaguely resembled an alveolar rhabdomyosarcoma. However, on immunohistochemistry, the tumor cells were S-100 and melan-A positive and desmin negative. A final diagnosis of amelanotic melanoma was made. Conclusion Awareness of the highly varied cytomorphology of amelanotic melanoma minimizes the diagnostic difficulty on fine needle aspiration smears. Suitable immunohistochemical markers are of great value in difficult situations.
引用
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页码:829 / 832
页数:4
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