A highly enantioselective asymmetric Darzens reaction catalysed by proline based efficient organocatalysts for the synthesis of di- and tri-substituted epoxides

被引：14

作者：

Ashokkumar, Veeramanoharan ^{[1
]}

Siva, Ayyanar ^{[1
]}

Chidambaram, R. Ramaswamy ^{[1
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Dept Inorgan Chem, Supramol & Organometall Chem Lab, Madurai 625021, Tamil Nadu, India

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 79期

关键词：

PHASE-TRANSFER CATALYSIS; GLYCIDIC AMIDES; ALPHA; BETA-UNSATURATED KETONES; DIASTEREOSELECTIVE SYNTHESIS; AROMATIC-ALDEHYDES; CARBONYL-COMPOUNDS; BETA-EPOXY KETONES; EPOXIDATION REACTIONS; HYDROGEN-PEROXIDE; AMMONIUM YLIDES;

D O I：

10.1039/c7cc06194c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new class of easily available and readily tunable proline based chiral organocatalysts was found to efficiently catalyse an unprecedented highly enantioselective asymmetric Darzens reaction of alpha-chloroketones and substituted alpha-chloroketones with various aldehydes, which directly produces optically active di- and tri- substituted chiral epoxides with higher product yields (up to 97%) and excellent ee's (up to 99%) under mild reaction conditions.

引用

收藏

页码：10926 / 10929

页数：4

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