Early Retinal Flow Changes after Vitreoretinal Surgery in Idiopathic Epiretinal Membrane Using Swept Source Optical Coherence Tomography Angiography

被引:28
作者
Mastropasqua, Rodolfo [1 ,2 ]
D'Aloisio, Rossella [3 ]
Viggiano, Pasquale [3 ]
Borrelli, Enrico [4 ]
Iafigliola, Carla [3 ]
Di Nicola, Marta [5 ]
Aharrh-Gnama, Agbeanda [3 ]
Di Marzio, Guido [3 ]
Toto, Lisa [3 ]
Mariotti, Cesare [1 ]
Carpineto, Paolo [3 ]
机构
[1] Polytech Univ Marche, Eye Clin, I-60126 Ancona, Italy
[2] Univ Modena & Reggio Emilia, Inst Ophthalmol, I-41121 Modena, Italy
[3] Univ G dAnnunzio, Dept Med & Sci Ageing, Ophthalmol Clin, I-66100 Chieti, Italy
[4] Univ Vita Salute, Dept Ophthalmol, IRCCS, Osped San Raffaele, I-20132 Milan, Italy
[5] Univ G dAnnunzio, Dept Med Oral & Biotechnol Sci, Lab Biostat, I-66100 Chieti, Italy
关键词
swept source optical coherence tomography angiography; vitreoretinal surgery; idiopathic epiretinal membrane; retinal vessel density; MACULAR DEGENERATION; QUANTIFICATION; ARCHITECTURE; PREVALENCE; DENSITY; LAYERS; EYES;
D O I
10.3390/jcm8122067
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
(1) Background: The aim of this observational cross-sectional work was to investigate early retinal vascular changes in patients undergoing idiopathic epiretinal membrane (iERM) surgery using swept source optical coherence tomography angiography (SS-OCTA); (2) Methods: 24 eyes of 24 patients who underwent vitrectomy with internal limiting membrane (ILM) peeling were evaluated pre- and postoperatively using SS-OCTA system (PLEX Elite 9000, Carl Zeiss Meditec Inc., Dublin, CA, USA). For each eye, five 6x6-mm OCTA volume scans were acquired by two observers independently. The en face images of superficial capillary plexus (SCP) were then exported to imageJ and a semi-automated algorithm was used for subsequent quantitative analysis. Perfusion density (PD), vessel length density (VLD), vessel diameter index (VDI) and vessel tortuosity (VT) of SCP were evaluated in both the parafoveal (2.5 mm diameter) and perifoveal areas (5.5 mm diameter); (3) Results: At OCTA analysis statistically significant differences were found between controls and diseased eyes for all parameters in parafoveal and perifoveal regions (p < 0.001; p < 0.05) except for perifoveal VLD. During 6-month follow up, both anatomical/perfusion and functional parameters showed a statistically significant improvement if compared to preoperative values. In detail, at one-month post vitrectomy, VLD and VT significantly changed in parafoveal region (p = 0.043; p = 0.045), while PD and VDI showed a trend of increase in both parafoveal and perifoveal region. At 6 months after surgery, PD, VLD and VT of parafoveal region significantly improved (p = 0.021, p = 0.018, p = 0.047 respectively). (4) Conclusions: SS-OCTA provides a quantitative and qualitative analysis of the superficial capillary plexus allowing for early vascular changes assessment after vitrectomy with iERM and ILM peeling.
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页数:11
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