Glycol Chitosan-Based Fluorescent Theranostic Nanoagents for Cancer Therapy

被引：28

作者：

Rhee, Jin-Kyu ^{[1
]}

Park, Ok Kyu ^{[2
]}

Lee, Aeju ^{[3
]}

Yang, Dae Hyeok ^{[4
]}

Park, Kyeongsoon ^{[2
]}

机构：

[1] Korea Basic Sci Inst, Western Seoul Ctr, Seoul 120140, South Korea

[2] Korea Basic Sci Inst, Chuncheon Ctr, Div Bioimaging, Gangwon Do 200701, South Korea

[3] Korea Inst Sci & Technol, Biomed Res Ctr, Seoul 136791, South Korea

[4] Catholic Univ Korea, Coll Med, Inst Cell & Tissue Engn, Seoul 137701, South Korea

来源：

MARINE DRUGS | 2014年 / 12卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

glycol chitosan; theranostics; nanosystem; fluorescence; cancer; SELF-ASSEMBLED NANOPARTICLES; FREE CLICK CHEMISTRY; PHOTODYNAMIC THERAPY; DRUG-DELIVERY; MULTIFUNCTIONAL NANOPARTICLES; ANTITUMOR EFFICACY; BIODISTRIBUTION; STABILITY; CARRIERS; SIRNA;

D O I：

10.3390/md12126038

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Theranostics is an integrated nanosystem that combines therapeutics with diagnostics in attempt to develop new personalized treatments with enhanced therapeutic efficacy and safety. As a promising therapeutic paradigm with cutting-edge technologies, theranostic agents are able to simultaneously deliver therapeutic drugs and diagnostic imaging agents and also monitor the response to therapy. Polymeric nanosystems have been intensively explored for biomedical applications to diagnose and treat various cancers. In recent years, glycol chitosan-based nanoagents have been developed as dual-purpose materials for simultaneous diagnosis and therapy. They have shown great potential in cancer therapies, such as chemotherapeutics and nucleic acid and photodynamic therapies. In this review, we summarize the recent progress and potential applications of glycol chitosan-based fluorescent theranostic nanoagents for cancer treatments and discuss their possible underlying mechanisms.

引用

页码：6038 / 6057

页数：20

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