The NHCs-mediated cross-coupling of aromatic aldehydes with benzyl halides: synthesis of α-aryl ketones

被引：62

作者：

Lin, Lu ^{[1
]}

Li, Yi ^{[1
]}

Du, Wenting ^{[1
]}

Deng, Wei-Ping ^{[1
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 27期

基金：

上海市自然科学基金;

关键词：

N-HETEROCYCLIC CARBENE; AROYLATION; SALTS;

D O I：

10.1016/j.tetlet.2010.05.003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new NHCs-mediated synthetic method was found to produce alpha-aryl ketones in 22-63% yields in one-pot process from the corresponding aromatic aldehydes and benzyl halides. This method is the first example of the NHCs-mediated intermolecular nucleophilic acylation of aromatic aldehydes with benzyl halides. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3571 / 3574

页数：4

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