Ten-Step Total Synthesis of (-)-Andranginine

被引：1

作者：

Zhao, Yulong ^{[1
]}

Li, Jiaxin ^{[1
]}

Ma, Ruize ^{[1
]}

He, Feifei ^{[1
]}

Shi, Hongliang ^{[1
]}

Duan, Xiaoguang ^{[1
]}

Li, Huilin ^{[1
]}

Xie, Xingang ^{[1
]}

She, Xuegong ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 37期

基金：

美国国家科学基金会;

关键词：

INDOLE ALKALOIDS; ASYMMETRIC-SYNTHESIS; ANDRANGININE; MELODINUS;

D O I：

10.1021/acs.orglett.2c02927

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of the indole alkaloid (-)-an-dranginine has been achieved in 10 steps. Key reactions of the synthesis include a nucleophilic addition of acetylenyl anion to chiral N-sulfinyl imine, an intramolecular N-alkylation reaction to close the C ring, and a dienyne metathesis cascade reaction to construct the DE rings. Meanwhile, 16-epi-(-)-andranginine was also obtained with the developed strategy.

引用

页码：6880 / 6883

页数：4

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