HCVpro: Hepatitis C virus protein interaction database

被引：70
作者：
Kwofie, Samuel K. [1 ]
Schaefer, Ulf [2 ]
Sundararajan, Vijayaraghava S. [1 ]
Bajic, Vladimir B. [2 ]
Christoffels, Alan [1 ]
机构：
[1] Univ Western Cape, S African Natl Bioinformat Inst, ZA-7535 Cape Town, South Africa
[2] King Abdullah Univ Sci & Technol, Computat Biosci Res Ctr CBRC, Thuwal 239556900, Saudi Arabia
来源：
INFECTION GENETICS AND EVOLUTION | 2011年 / 11卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
Hepatitis C virus; Hepatocellular carcinoma; Database; Protein-protein interaction; Curation; Network; HEPATOCELLULAR-CARCINOMA; CORE PROTEIN; INTERACTION NETWORK; TARGET GENES; PATHWAY; NS5A; IDENTIFICATION; EXPRESSION; RESOURCE; RECEPTOR;
D O I：
10.1016/j.meegid.2011.09.001
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
It is essential to catalog characterized hepatitis C virus (HCV) protein-protein interaction (PPI) data and the associated plethora of vital functional information to augment the search for therapies, vaccines and diagnostic biomarkers. In furtherance of these goals, we have developed the hepatitis C virus protein interaction database (HCVpro) by integrating manually verified hepatitis C virus-virus and virus-human protein interactions curated from literature and databases. HCVpro is a comprehensive and integrated HCV-specific knowledgebase housing consolidated information on PPIs, functional genomics and molecular data obtained from a variety of virus databases (VirHostNet, VirusMint, HCVdb and euHCVdb), and from BIND and other relevant biology repositories. HCVpro is further populated with information on hepatocellular carcinoma (HCC) related genes that are mapped onto their encoded cellular proteins. Incorporated proteins have been mapped onto Gene Ontologies, canonical pathways, Online Mendelian Inheritance in Man (OMIM) and extensively cross-referenced to other essential annotations. The database is enriched with exhaustive reviews on structure and functions of HCV proteins, current state of drug and vaccine development and links to recommended journal articles. Users can query the database using specific protein identifiers (IDs), chromosomal locations of a gene, interaction detection methods, indexed PubMed sources as well as HCVpro, BIND and VirusMint IDs. The use of HCVpro is free and the resource can be accessed via http://apps.sanbi.ac.za/hcvpro/ or http://cbrc.kaustedu.sa/hcvpro/. (C) 2011 Elsevier B.V. All rights reserved.
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页码：1971 / 1977
页数：7
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