Model for the regulation of energy balance and adiposity by the central nervous system

被引：1
作者：
Schwartz, MW
Baskin, DG
Kaiyala, KJ
Woods, SC
机构：
[1] Univ Washington, Dept Med, Harborview Med Ctr, Seattle, WA 98108 USA
[2] Univ Washington, Dept Biol Struct, Harborview Med Ctr, Seattle, WA 98108 USA
[3] Univ Washington, Dept Psychol, Harborview Med Ctr, Seattle, WA 98108 USA
[4] VA Puget Sound Hlth Care Syst, Seattle, WA USA
[5] Univ Cincinnati, Dept Psychiat, Cincinnati, OH 45221 USA
来源：
AMERICAN JOURNAL OF CLINICAL NUTRITION | 1999年 / 69卷 / 04期
关键词：
body weight; adipose tissue; food intake; insulin; leptin; neuropeptide Y; glucocorticoids; obesity; energy balance; central nervous system; homeostasis; central effector pathways; arcuate nucleus; paraventricular nucleus; review;
D O I：
暂无
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
In 1995, we described a new model for adiposity regulation. Since then, data regarding the biology of body weight regulation has accumulated at a remarkable rate and has bath modified and strengthened our understanding of ibis homeostatic system. In this review we integrate new information into a revised model for further understanding this important regulatory process. Our model of energy homeostasis proposes that long-term adiposity-related signals such as insulin and leptin influence the neuronal activity of central effector pathways that serve as controllers of energy balance.
引用
收藏
页码：584 / 596
页数：13
相关论文
共 50 条
  • [41] The central nervous system control of energy homeostasis: High fat diet induced hypothalamic microinflammation and obesity
    Yan, Lihong
    Li, Juxue
    BRAIN RESEARCH BULLETIN, 2022, 185 : 99 - 106
  • [42] Contribution made by parabiosis to the understanding of energy balance regulation
    Harris, Ruth B. S.
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2013, 1832 (09): : 1449 - 1455
  • [43] Chemokines and chemokine receptors in autoimmune encephalomyelitis as a model for central nervous system inflammatory disease regulation
    Dogan, RNE
    Karpus, WJ
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2004, 9 : 1500 - 1505
  • [44] Participation of the central melanocortin system in metabolic regulation and energy homeostasis
    Jin Kwon Jeong
    Jae Geun Kim
    Byung Ju Lee
    Cellular and Molecular Life Sciences, 2014, 71 : 3799 - 3809
  • [45] Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice
    Egecioglu, Emil
    Ploj, Karolina
    Xu, Xiufeng
    Bjursell, Mikael
    Salome, Nicolas
    Andersson, Niklas
    Ohlsson, Claes
    Taube, Magdalena
    Hansson, Caroline
    Bohlooly-Y, Mohammad
    Morgan, David G. A.
    Dickson, Suzanne L.
    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2009, 297 (03): : E708 - E716
  • [46] REGULATION OF SOLUTE AND WATER-BALANCE AND CELL-VOLUME IN THE CENTRAL-NERVOUS-SYSTEM
    STRANGE, K
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1992, 3 (01): : 12 - 27
  • [47] Central nervous system regulation of hepatic lipid and lipoprotein metabolism
    Taher, Jennifer
    Farr, Sarah
    Adeli, Khosrow
    CURRENT OPINION IN LIPIDOLOGY, 2017, 28 (01) : 32 - 38
  • [48] Central Nervous System Imprinting of the G Protein Gsα and Its Role in Metabolic Regulation
    Chen, Min
    Wang, Jie
    Dickerson, Kathryn E.
    Kelleher, James
    Xie, Tao
    Gupta, Divakar
    Lai, Edwin W.
    Pacak, Karel
    Gavrilova, Oksana
    Weinstein, Lee S.
    CELL METABOLISM, 2009, 9 (06) : 548 - 555
  • [49] The effects of insulin on the central nervous system -: Focus on appetite regulation
    Pliquett, R. U.
    Fuehrer, D.
    Falk, S.
    Zysset, S.
    von Cramon, D. Y.
    Stumvoll, M.
    HORMONE AND METABOLIC RESEARCH, 2006, 38 (07) : 442 - 446
  • [50] Central nervous system regulation of intestinal lipid and lipoprotein metabolism
    Farr, Sarah
    Taher, Jennifer
    Adeli, Khosrow
    CURRENT OPINION IN LIPIDOLOGY, 2016, 27 (01) : 1 - 7
12345