Model for the regulation of energy balance and adiposity by the central nervous system

被引：1
作者：
Schwartz, MW
Baskin, DG
Kaiyala, KJ
Woods, SC
机构：
[1] Univ Washington, Dept Med, Harborview Med Ctr, Seattle, WA 98108 USA
[2] Univ Washington, Dept Biol Struct, Harborview Med Ctr, Seattle, WA 98108 USA
[3] Univ Washington, Dept Psychol, Harborview Med Ctr, Seattle, WA 98108 USA
[4] VA Puget Sound Hlth Care Syst, Seattle, WA USA
[5] Univ Cincinnati, Dept Psychiat, Cincinnati, OH 45221 USA
来源：
AMERICAN JOURNAL OF CLINICAL NUTRITION | 1999年 / 69卷 / 04期
关键词：
body weight; adipose tissue; food intake; insulin; leptin; neuropeptide Y; glucocorticoids; obesity; energy balance; central nervous system; homeostasis; central effector pathways; arcuate nucleus; paraventricular nucleus; review;
D O I：
暂无
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
In 1995, we described a new model for adiposity regulation. Since then, data regarding the biology of body weight regulation has accumulated at a remarkable rate and has bath modified and strengthened our understanding of ibis homeostatic system. In this review we integrate new information into a revised model for further understanding this important regulatory process. Our model of energy homeostasis proposes that long-term adiposity-related signals such as insulin and leptin influence the neuronal activity of central effector pathways that serve as controllers of energy balance.
引用
收藏
页码：584 / 596
页数：13
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