Exploring the Therapeutic Potential of Membrane Transport Proteins: Focus on Cancer and Chemoresistance

被引：17
|
作者：
Almasi, Shekoufeh [1 ]
El Hiani, Yassine [2 ]
机构：
[1] Univ Ottawa, Fac Med, Dept Cellular & Mol Med, Ottawa, ON KIH 8M5, Canada
[2] Dalhousie Univ, Dept Physiol & Biophys, Fac Med, Halifax, NS B3H 4R2, Canada
来源：
CANCERS | 2020年 / 12卷 / 06期
基金：
加拿大自然科学与工程研究理事会;
关键词：
membrane transporters; pumps; ion channels; cancers; chemoresistance; CELL LUNG-CANCER; GATED SODIUM-CHANNEL; ETHYL 2-AMINO-6-(3,5-DIMETHOXYPHENYL)-4-(2-ETHOXY-2-OXOETHYL)-4H-CHROMENE-3-CARBOXYLAT CXL017; EPITHELIAL-MESENCHYMAL TRANSITION; CALCIUM-PUMP EXPRESSION; V-ATPASE INHIBITION; ION CHANNELS; H+-ATPASE; TUMOR-GROWTH; COLORECTAL-CANCER;
D O I：
10.3390/cancers12061624
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Improving the therapeutic efficacy of conventional anticancer drugs represents the best hope for cancer treatment. However, the shortage of druggable targets and the increasing development of anticancer drug resistance remain significant problems. Recently, membrane transport proteins have emerged as novel therapeutic targets for cancer treatment. These proteins are essential for a plethora of cell functions ranging from cell homeostasis to clinical drug toxicity. Furthermore, their association with carcinogenesis and chemoresistance has opened new vistas for pharmacology-based cancer research. This review provides a comprehensive update of our current knowledge on the functional expression profile of membrane transport proteins in cancer and chemoresistant tumours that may form the basis for new cancer treatment strategies.
引用
收藏
页码：1 / 31
页数：31
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