Identification of a highly specific hydroxyapatite-binding peptide using phage display

被引：89

作者：

Roy, Marc D. ^{[1
]}

Stanley, Scott K. ^{[1
]}

Amis, Eric J. ^{[1
]}

Becker, Matthew L. ^{[1
]}

机构：

[1] NIST, Div Polymers, Gaithersburg, MD 20899 USA

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 10期

关键词：

D O I：

10.1002/adma.200702322

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A peptide sequence SVSVGMKPSPRP that selectively recognizes hydroxyapatite (HA) is identified by using a phage display approach. The engineered sequence exhibits chemical and structural specificity for HA over calcium carbonate and HA's amorphous calcium phosphate precursor. In situ binding to HA in a tooth cross section further demonstrates the sequence specificity and utility in nondestructive imaging applications.

引用

页码：1830 / +

页数：8

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