Identification of a highly specific hydroxyapatite-binding peptide using phage display

被引:89
|
作者
Roy, Marc D. [1 ]
Stanley, Scott K. [1 ]
Amis, Eric J. [1 ]
Becker, Matthew L. [1 ]
机构
[1] NIST, Div Polymers, Gaithersburg, MD 20899 USA
关键词
D O I
10.1002/adma.200702322
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A peptide sequence SVSVGMKPSPRP that selectively recognizes hydroxyapatite (HA) is identified by using a phage display approach. The engineered sequence exhibits chemical and structural specificity for HA over calcium carbonate and HA's amorphous calcium phosphate precursor. In situ binding to HA in a tooth cross section further demonstrates the sequence specificity and utility in nondestructive imaging applications.
引用
收藏
页码:1830 / +
页数:8
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