Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress

被引：93

作者：

Sanchez, Claudia A. ^{[1
]}

Rodriguez, Emma ^{[1
]}

Varela, Elvira ^{[1
]}

Zapata, Estrella ^{[1
]}

Paez, Araceli ^{[1
]}

Masso, Felipe A. ^{[1
]}

Montano, Luis F. ^{[2
]}

Lopez-Marure, Rebeca ^{[1
]}

机构：

[1] Inst Nacl Cardiol Ignacio Chavez, Dept Biol Celular, Mexico City 14080, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Lab Inmunol, Mexico City, DF, Mexico

来源：

CANCER INVESTIGATION | 2008年 / 26卷 / 07期

关键词：

statins; cell cycle; cell death; oxidative stress; MCF-7;

D O I：

10.1080/07357900701874658

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Statins have antiproliferative and anti-tumoral effects in MCF-7 cells. We determined the effect of statins upon MCF-7 cell cycle, toxicity, cell death, reactive oxygen species (ROS) production and mitochondrial membrane potential. Fluvastatin, simvastatin and atorvastatin inhibited cell proliferation. Antiproliferation was associated with a decrease in the DNA synthesis and a cell cycle arrest in the G1 and G2/M phases. A loss in the mitochondrial membrane potential was observed with fluvastatin. Statins induced increase in ROS production that was associated with cell death, which was abrogated by the antioxidant NAC. Our results suggest that the cytotoxic effect observed is mediated by an oxidative stress.

引用

页码：698 / 707

页数：10

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