Sorting cells by size, shape and deformability

被引：220

作者：

Beech, Jason P. ^{[1
]}

Holm, Stefan H. ^{[1
]}

Adolfsson, Karl ^{[1
]}

Tegenfeldt, Jonas O. ^{[1
,2
]}

机构：

[1] Lund Univ, nmC LU, Div Solid State Phys, S-22100 Lund, Sweden

[2] Univ Gothenburg, Dept Phys, Gothenburg, Sweden

来源：

LAB ON A CHIP | 2012年 / 12卷 / 06期

基金：

瑞典研究理事会;

关键词：

RED-BLOOD-CELL;

D O I：

10.1039/c2lc21083e

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

While size has been widely used as a parameter in cellular separations, in this communication we show how shape and deformability, a mainly untapped source of specificity in preparative and analytical microfluidic devices can be measured and used to separate cells.

引用

页码：1048 / 1051

页数：4

共 18 条

[1]

[Anonymous], 2003, Cell Membrane: The Red Blood Cells as a Model

[2]

Bow H, 2011, LAB CHIP, V11, P1065, DOI [10.1039/c0lc00472c, 10.1039/c01c00472c]

[3] DEFORMATION AND FLOW OF RED-BLOOD-CELLS IN A SYNTHETIC LATTICE - EVIDENCE FOR AN ACTIVE CYTOSKELETON [J].

BRODY, JP ;

HAN, YQ ;

AUSTIN, RH ;

BITENSKY, M .

BIOPHYSICAL JOURNAL, 1995, 68 (06) :2224-2232

[4]

Davis J. A., 2008, THESIS PRINCETON U

[5] Deterministic hydrodynamics: Taking blood apart [J].

Davis, John A. ;

Inglis, David W. ;

Morton, Keith J. ;

Lawrence, David A. ;

Huang, Lotien R. ;

Chou, Stephen Y. ;

Sturm, James C. ;

Austin, Robert H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (40) :14779-14784

[6] The optical stretcher:: A novel laser tool to micromanipulate cells [J].

Guck, J ;

Ananthakrishnan, R ;

Mahmood, H ;

Moon, TJ ;

Cunningham, CC ;

Käs, J .

BIOPHYSICAL JOURNAL, 2001, 81 (02) :767-784

[7]

HARDEMAN MR, 1994, CLIN HEMORHEOL, V14, P605

[8] Separation of parasites from human blood using deterministic lateral displacement [J].

Holm, Stefan H. ;

Beech, Jason P. ;

Barrett, Michael P. ;

Tegenfeldt, Jonas O. .

LAB ON A CHIP, 2011, 11 (07) :1326-1332

[9] Deformability based cell margination-A simple microfluidic design for malaria-infected erythrocyte separation [J].

Hou, Han Wei ;

Bhagat, Ali Asgar S. ;

Chong, Alvin Guo Lin ;

Mao, Pan ;

Tan, Kevin Shyong Wei ;

Han, Jongyoon ;

Lim, Chwee Teck .

LAB ON A CHIP, 2010, 10 (19) :2605-2613

[10] Continuous particle separation through deterministic lateral displacement [J].

Huang, LR ;

Cox, EC ;

Austin, RH ;

Sturm, JC .

SCIENCE, 2004, 304 (5673) :987-990

← 1 2 →