Sorting cells by size, shape and deformability

被引:214
作者
Beech, Jason P. [1 ]
Holm, Stefan H. [1 ]
Adolfsson, Karl [1 ]
Tegenfeldt, Jonas O. [1 ,2 ]
机构
[1] Lund Univ, nmC LU, Div Solid State Phys, S-22100 Lund, Sweden
[2] Univ Gothenburg, Dept Phys, Gothenburg, Sweden
基金
瑞典研究理事会;
关键词
RED-BLOOD-CELL;
D O I
10.1039/c2lc21083e
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
While size has been widely used as a parameter in cellular separations, in this communication we show how shape and deformability, a mainly untapped source of specificity in preparative and analytical microfluidic devices can be measured and used to separate cells.
引用
收藏
页码:1048 / 1051
页数:4
相关论文
共 18 条
  • [1] [Anonymous], 2003, Cell Membrane: The Red Blood Cells as a Model
  • [2] Bow H, 2011, LAB CHIP, V11, P1065, DOI [10.1039/c0lc00472c, 10.1039/c01c00472c]
  • [3] DEFORMATION AND FLOW OF RED-BLOOD-CELLS IN A SYNTHETIC LATTICE - EVIDENCE FOR AN ACTIVE CYTOSKELETON
    BRODY, JP
    HAN, YQ
    AUSTIN, RH
    BITENSKY, M
    [J]. BIOPHYSICAL JOURNAL, 1995, 68 (06) : 2224 - 2232
  • [4] Davis J. A., 2008, THESIS PRINCETON U
  • [5] Deterministic hydrodynamics: Taking blood apart
    Davis, John A.
    Inglis, David W.
    Morton, Keith J.
    Lawrence, David A.
    Huang, Lotien R.
    Chou, Stephen Y.
    Sturm, James C.
    Austin, Robert H.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (40) : 14779 - 14784
  • [6] The optical stretcher:: A novel laser tool to micromanipulate cells
    Guck, J
    Ananthakrishnan, R
    Mahmood, H
    Moon, TJ
    Cunningham, CC
    Käs, J
    [J]. BIOPHYSICAL JOURNAL, 2001, 81 (02) : 767 - 784
  • [7] HARDEMAN MR, 1994, CLIN HEMORHEOL, V14, P605
  • [8] Separation of parasites from human blood using deterministic lateral displacement
    Holm, Stefan H.
    Beech, Jason P.
    Barrett, Michael P.
    Tegenfeldt, Jonas O.
    [J]. LAB ON A CHIP, 2011, 11 (07) : 1326 - 1332
  • [9] Deformability based cell margination-A simple microfluidic design for malaria-infected erythrocyte separation
    Hou, Han Wei
    Bhagat, Ali Asgar S.
    Chong, Alvin Guo Lin
    Mao, Pan
    Tan, Kevin Shyong Wei
    Han, Jongyoon
    Lim, Chwee Teck
    [J]. LAB ON A CHIP, 2010, 10 (19) : 2605 - 2613
  • [10] Continuous particle separation through deterministic lateral displacement
    Huang, LR
    Cox, EC
    Austin, RH
    Sturm, JC
    [J]. SCIENCE, 2004, 304 (5673) : 987 - 990