Stereoselective hydrolysis of racemic ethyl 4-chloro-3-hydroxybutyrate by a lipase

被引：3

作者：

Chung, Sunho ^{[1
]}

Hwang, Yunesahng ^{[2
]}

机构：

[1] Enzytech Ltd, Inst Bio Chem, Dept Bioproc Engn, Taejon 305805, South Korea

[2] Korean Minjok Leadership Acad, Gangwon Do, South Korea

来源：

BIOCATALYSIS AND BIOTRANSFORMATION | 2008年 / 26卷 / 04期

关键词：

ethyl; 4-chloro-3-hydroxybutyrate; hydrolysis; 3-hydroxy-gamma-butyrolactone; Novozym; 435; stereoselectivity;

D O I：

10.1080/10242420801897585

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The stereoselective hydrolysis of racemic ethyl 4-chloro-3-hydroxybutyrate (ECHB) was performed by using Novozym 435 lipase in an aqueous phase. It was found that racemic ECHB was hydrolysed to (R)-ECHB and (S)-3-hydroxy-gamma-butyrolactone (HGBL) via (S)-4-chloro-3-hydroxybutyric acid. From this result, (R)-ECHB (99%ee) was produced in a good yield on a preparative scale.

引用

页码：327 / 330

页数：4

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