Pegfilgrastim overdose: case report and review of the literature

被引：2

作者：

Kaidar-Person, Orit ^{[1
]}

Moskovitz, Mor ^{[1
]}

Charas, Tomer ^{[1
]}

Alsharbati, Wasim ^{[1
]}

Haim, Nissim ^{[1
]}

机构：

[1] Rambam Hlth Care Campus, Div Oncol, IL-31096 Haifa, Israel

来源：

MEDICAL ONCOLOGY | 2011年 / 28卷

关键词：

Chemotherapy; G-CSF; Neutropenia; Overdose; Pegfilgrastim; BREAST-CANCER; RESPIRATORY-DISTRESS; CELL MOBILIZATION; G-CSF; PATIENT; CHEMOTHERAPY; NEUTROPENIA; TOXICITY; EFFICACY; SUPPORT;

D O I：

10.1007/s12032-010-9751-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Single-dose pegfilgrastim is commonly used for the prophylaxis of neutropenia in patients receiving myelotoxic chemotherapy. We report a case of a 69-year-old man who was treated with chemotherapy for small-cell lung cancer and mistakenly self-administered a 36 mg overdose of pegfilgrastim, a sixfold increase over the scheduled dose.

引用

页码：S697 / S698

页数：2

共 11 条

[1]

Becker P S, 1997, Biol Blood Marrow Transplant, V3, P45

[2] Efficacy of pegfilgrastim and darbepoetin alfa as hematopoietic support for dose-dense every-2-week adjuvant breast cancer chemotherapy [J].

Burstein, HJ ;

Parker, LM ;

Keshaviah, A ;

Doherty, J ;

Partridge, AH ;

Schapira, L ;

Ryan, PD ;

Younger, J ;

Harris, LN ;

Moy, B ;

Come, SE ;

Schumer, ST ;

Bunnell, CA ;

Haldoupis, M ;

Gelman, R ;

Winer, EP .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (33) :8340-8347

[3] Pegfilgrastim [J].

Curran, MP ;

Goa, KL .

DRUGS, 2002, 62 (08) :1207-1213

[4] Respiratory distress and sudden death of a patient with GSDIb chronic neutropenia: possible role of pegfilgrastim [J].

Donadieu, Jean ;

Beaupain, Blandine ;

Rety-Jacob, Frederique ;

Nove-Josserand, Raphaelle .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 (08) :1175-1177

[5] Bullous Sweet's syndrome in congenital neutropenia: Association with pegfilgrastim [J].

Draper, BK ;

Robbins, JR ;

Stricklin, GP .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2005, 52 (05) :901-905

[6] Similar favorable outcome of pegfilgrastim overdose in patients with different age and underlying disease [J].

Dufour, Carlo ;

Cappelli, Barbara ;

Calvillo, Michaela ;

Fioredda, Francesca ;

Tonelli, Rossella ;

Crocchiolo, Roberto .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 (04) :684-685

[7] Prolonged neutropenia after dose-dense chemotherapy with pegfilgrastim [J].

Ishiguro, H. ;

Kitano, T. ;

Yoshibayashi, H. ;

Toi, M. ;

Ueno, T. ;

Yasuda, H. ;

Yanagihara, K. ;

Garbo, C. L. ;

Fukushima, M. .

ANNALS OF ONCOLOGY, 2008, 19 (05)

[8] Efficacy and toxicity of a high-dose G-CSF schedule for peripheral blood progenitor cell mobilization in healthy donors [J].

Martínez, C ;

Urbano-Ispizua, A ;

Marín, P ;

Merino, A ;

Rovira, M ;

Carreras, E ;

Montserrat, E .

BONE MARROW TRANSPLANTATION, 1999, 24 (12) :1273-1278

[9]

Pitini V, 2000, HAEMATOLOGICA, V85, P559

[10] IMPAIRMENT IN GAS-EXCHANGE AFTER GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF) IN A PATIENT WITH THE ADULT-RESPIRATORY-DISTRESS-SYNDROME [J].

SCHILERO, GJ ;

OROPELLO, J ;

BENJAMIN, E .

CHEST, 1995, 107 (01) :276-278

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