Transetherification-mediated E-ring opening and stereoselective "Red-Ox" modification of furostan

被引：7

作者：

Cheun, Young ^{[1
]}

Koag, Myong Chul ^{[1
]}

Kou, Yi ^{[1
]}

Warnken, Zachary ^{[1
]}

Lee, Seongmin ^{[1
]}

机构：

[1] Univ Texas Austin, Coll Pharm, Div Med Chem, Austin, TX 78712 USA

来源：

STEROIDS | 2012年 / 77卷 / 03期

关键词：

E-ring opening; Cephalostatin; Transetherification; NATURAL-PRODUCTS; CEPHALOSTATIN; HECOGENIN; SPIROKETALS; HEMISPHERE; PROTOCOL; UNIT;

D O I：

10.1016/j.steroids.2011.12.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have developed a novel E-ring opening method for furostan, and applied it to prepare D-ring modified steroids, which can be used to synthesize cephalostatin analogs. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：276 / 281

页数：6