A Boron-Based Synthesis of the Natural Product (+)- trans-Dihydrolycoricidine

被引：25

作者：

Poe, Sarah L. ^{[1
]}

Morken, James P. ^{[1
]}

机构：

[1] Boston Coll, Dept Chem, Chestnut Hill, MA 02467 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 18期

基金：

美国国家科学基金会;

关键词：

allylation; asymmetric synthesis; natural products; oxidation; ANTINEOPLASTIC AGENTS; AMARYLLIDACEAE CONSTITUENTS; NARCICLASINE; ALKALOIDS; PANCRATISTATIN; LYCORICIDINE; 1,3-DIENES; CHEMISTRY;

D O I：

10.1002/anie.201007135

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Diastereoselective diboration results in the highly selective 1,4-dihydroxylation of chiral cyclohexadienes (see scheme). Together with the catalytic enantioselective conjugate allylboration, the diene diboration facilitates the asymmetric synthesis of the cytotoxic agent (+)-trans- dihydrolycoricidine (1). pin=pinacol. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：4189 / 4192

页数：4

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