Screening and identification of neuroprotective compounds produced by Lactobacillus paracasei subsp paracasei NTU 101

被引：3

作者：

Cheng, Meng-Chun ^{[1
]}

Leu, Yann-Lii ^{[2
]}

Tsai, Tsung-Yu ^{[3
]}

Pan, Tzu-Ming ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Biochem Sci & Technol, Taipei, Taiwan

[2] Chang Gung Univ, Grad Inst Nat Prod, Taoyuan, Taiwan

[3] Fu Jen Catholic Univ, Dept Food Sci, 510 Zhongzheng Rd, New Taipei 24205, Taiwan

来源：

JOURNAL OF FUNCTIONAL FOODS | 2016年 / 26卷

关键词：

Lactobacillus paracasei subsp paracasei NTU 101; Fermentation products; Neuroprotective compounds; Nuclear magnetic resonance; Glyceryl 1,3-dipalmitate; LACTIC-ACID BACTERIA; OXYGEN-GLUCOSE DEPRIVATION; CYTOCHROME-C RELEASE; SOY SKIM MILK; PC12; CELLS; FERMENTED MILK; INDUCED APOPTOSIS; FEMORAL BONE; LACTATE; BRAIN;

D O I：

10.1016/j.jff.2016.07.021

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Ischaemia/reperfusion injury plays important roles in the morbidity and mortality associated with ischaemic strokes. We investigated the neuroprotective effects of ethanol extract fractions isolated form Lactobacillus paracasei subsp. paracasei NTU 101 (NTU 101) fermentation products, against oxygen-glucose deprivation and reperfusion (OGD/R) in vitro. Pretreatment with 1000 mu g/mL water or ethanol extracts reversed OGD/R-induced cell death by 17% and 42%, respectively, while post-treatment with these extracts reversed OGD/R-induced cell death by 3% and 27%, respectively. A major neuroprotective compound extracted from NTU 101 fermentation products, glyceryl 1,3-dipalmitate (GD), was characterised using ultra-performance liquid chromatography-mass spectrometry and nuclear magnetic resonance. Pre-treatment with GD modulated the expression of inducible nitric oxide synthase, nuclear factor-kappa B, and Bcl-2-associated X, compared with OGD/R group. Our findings indicate the potential of the therapeutic application of GD in the prevention and treatment of cerebral ischaemic and neurodegenerative diseases. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：238 / 248

页数：11

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