Bone morphogenetic protein-7 induced bone marrow stromal cells differentiate into neuron-like cells

被引：0

作者：

Li, Kuanxin ^{[1
]}

Zhang, Yuling ^{[1
,2
]}

Wang, Weishan ^{[1
]}

He, Bin ^{[1
]}

Sun, Jianhua ^{[1
]}

Dong, Jinbo ^{[1
]}

Shi, Chenhui ^{[1
]}

机构：

[1] Shihezi Univ, Coll Med, Affiliated Hosp 1, Dept Orthoped 1, Shihezi 832008, Xinjiang Uygur, Peoples R China

[2] Shihezi Univ, Coll Med, Affiliated Hosp 1, Dept Sci Educ, Shihezi 832008, Xinjiang Uygur, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 22期

关键词：

bone morphogenetic protein-7; differentiation; bone marrow stromal cells; neuron-like cells; microtubule-associated protein 2; intermediate filament protein; glial fibrillary acidic protein; neural regeneration; MESENCHYMAL STEM-CELLS;

D O I：

10.3969/j.issn.1673-5374.2011.22.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bone morphogenetic protein-7 is widely accepted as an inducer for bone marrow stem cells differentiating into osteoblasts and chondrocytes. Whether bone marrow stromal cells differentiate into neuron-like cells remains unclear. The current study examined the presence of positive cells for intermediate filament protein and microtubule associated protein-2 in the cytoplasm of bone marrow stromal cells induced by bone morphogenetic protein-7 under an inverted microscope, while no expression of glial fibrillary acidic protein was found. Reverse transcription PCR electrophoresis also revealed a positive target band for intermediate filament protein and microtubule-associated protein 2 mRNA. These results confirmed that bone morphogenetic protein-7 induces rat bone marrow stromal cells differentiating into neuron-like cells.

引用

页码：1685 / 1690

页数：6

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