Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo

被引：293
作者：
Mensch, Sigrid [1 ]
Baraban, Marion [1 ]
Almeida, Rafael [1 ]
Czopka, Tim [1 ]
Ausborn, Jessica [2 ]
El Manira, Abdeljabbar [2 ]
Lyons, David A. [1 ]
机构：
[1] Univ Edinburgh, Euan MacDonald Ctr Motor Neurone Dis Res, Ctr Multiple Sclerosis Res, Ctr Neuroregenerat, Edinburgh, Midlothian, Scotland
[2] Karolinska Inst, Dept Neurosci, Stockholm, Sweden
来源：
NATURE NEUROSCIENCE | 2015年 / 18卷 / 05期
基金：
英国惠康基金; 英国生物技术与生命科学研究理事会;
关键词：
RETICULOSPINAL NEURONS; ELECTRICAL-ACTIVITY; ZEBRAFISH; SYSTEM; BRAIN; MORPHOGENESIS; MATURATION; GENERATION; DYNAMICS; BEHAVIOR;
D O I：
10.1038/nn.3991
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The myelination of axons by oligodendrocytes markedly affects CNS function, but how this is regulated by neuronal activity in vivo is not known. We found that blocking synaptic vesicle release impaired CNS myelination by reducing the number of myelin sheaths made by individual oligodendrocytes during their short period of formation. We also found that stimulating neuronal activity increased myelin sheath formation by individual oligodendrocytes. These data indicate that neuronal activity regulates the myelinating capacity of single oligodendrocytes.
引用
收藏
页码：628 / +
页数：5
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