The micronucleus test in rat erythrocytes from bone marrow, spleen and peripheral blood:: the response to low doses of ionizing radiation, cyclophosphamide and vincristine determined by flow cytometry
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Abramsson-Zetterberg, L
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机构:Uppsala Univ, Dept Genet, S-75007 Uppsala, Sweden
Abramsson-Zetterberg, L
Grawé, J
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机构:Uppsala Univ, Dept Genet, S-75007 Uppsala, Sweden
Grawé, J
Zetterberg, G
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机构:Uppsala Univ, Dept Genet, S-75007 Uppsala, Sweden
Zetterberg, G
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[1] Uppsala Univ, Dept Genet, S-75007 Uppsala, Sweden
[2] Univ Stockholm, Dept Genet & Cellular Toxicol, S-10691 Stockholm, Sweden
The frequency of micronucleated polychromatic erythrocytes (fMPCE) was determined in samples from bone marrow, spleen and peripheral blood of rats exposed to low doses of X-rays, cyclophosphamide or vincristine. The fMPCE values were lower in the peripheral blood than in bone marrow or spleen. This is due to the elimination of MPCE from the circulating blood, which was confirmed by the results from prolonged exposure of rats to gamma-radiation. When the analysis was restricted to the youngest PCE in peripheral blood, the sensitivity of the assay was considerably improved. This can be reproducibly achieved with the flow cytometric analysis. (C) 1999 Elsevier Science B.V. All rights reserved.
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Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USA
Criswell, KA
Krishna, G
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Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USA
Krishna, G
Zielinski, D
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Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USA
Zielinski, D
Urda, GA
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Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USA
Urda, GA
Theiss, JC
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Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USA
Theiss, JC
Juneau, P
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Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USA
Juneau, P
Bleavins, MR
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Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USA
机构:
Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USA
Criswell, KA
Krishna, G
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机构:
Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USA
Krishna, G
Zielinski, D
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Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USA
Zielinski, D
Urda, GA
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Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USA
Urda, GA
Theiss, JC
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机构:
Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USA
Theiss, JC
Juneau, P
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机构:
Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USA
Juneau, P
Bleavins, MR
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h-index: 0
机构:
Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res, Pathol & Expt Toxicol, Ann Arbor, MI 48105 USA