Statin Therapy and the Risk of Viral Infection: A Retrospective Population-Based Cohort Study

被引：3

作者：

Wu, Biing-Ru ^{[1
,2
]}

Chen, Ding-Han ^{[1
]}

Liao, Wei-Chih ^{[1
,3
,4
]}

Ho, Wen-Chao ^{[5
,6
]}

Yin, Ming-Chien ^{[2
]}

Lin, Cheng-Li ^{[7
]}

Chou, Chia-Hui ^{[8
]}

Peng, Yi-Hao ^{[5
,9
]}

机构：

[1] China Med Univ, China Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Med, Taichung 404327, Taiwan

[2] China Med Univ, China Med Univ Hosp, Dept Resp Therapy, Taichung 404327, Taiwan

[3] China Med Univ, China Med Univ Hosp, Hyperbar Oxygen Therapy Ctr, Taichung 404327, Taiwan

[4] China Med Univ, Sch Med, Taichung 404333, Taiwan

[5] China Med Univ, Dept Publ Hlth, Taichung 406040, Taiwan

[6] Asia Univ, Dept Nursing, Taichung 413305, Taiwan

[7] China Med Univ Hosp, Management Off Hlth Data, Taichung 404327, Taiwan

[8] China Med Univ, China Med Univ Hosp, Dept Internal Med, Div Infect Dis, Taichung 404327, Taiwan

[9] Asia Univ, Asia Univ Hosp, Dept Resp Therapy, Taichung 413505, Taiwan

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 19期

关键词：

statin therapy; viral infection; epidemiology; cohort study; propensity score matching; INFLUENZA-A VIRUS; MORTALITY; IMMUNITY; REDUCE;

D O I：

10.3390/jcm11195626

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Statins exert cholesterol-independent beneficial effects, including immunomodulatory effects. In this study, we attempted to investigate the association between statin therapy and the risk of viral infection. We conducted a retrospective cohort study using data from Taiwan's National Health Insurance Research Database. We identified patients with hyperlipidemia and divided them into two cohorts: statin users and statin nonusers. A 1:1 propensity score matching was conducted between the two cohorts, and a Cox proportional hazards model was used to evaluate the risk of viral infection. Overall, a total of 20,202 patients were included in each cohort. The median follow-up durations were 4.41 and 6.90 years for statin nonusers and users, respectively. The risk of viral infection was 0.40-fold (95% confidence interval = 0.38-0.41) in statin users than in statin nonusers after adjustment for potential confounders. Statin treatment was associated with a significantly lower risk of viral infection in all age groups older than 18 years in both men and women. Moreover, the risk of viral infection substantially reduced as the duration of statin treatment increased. Our findings suggest that statin therapy is associated with a significantly lower risk of viral infection in patients with hyperlipidemia.

引用

页数：9

共 29 条

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