Feasibility of induction heating using a sintered MgFe2O4 needle for minimally invasive breast cancer therapy

被引：0

作者：

Yukumi, Shungo ^{[1
]}

Watanabe, Yuji ^{[1
]}

Horiuchi, Atsushi ^{[1
]}

Doi, Takashi ^{[1
]}

Sato, Kohichi ^{[1
]}

Yoshida, Motohira ^{[1
]}

Maehara, Tsunehiro ^{[2
]}

Aono, Hiromichi ^{[3
]}

Naohara, Takashi ^{[3
]}

Kawachi, Kanji ^{[1
]}

机构：

[1] Ehime Univ Shitsukawa, Dept Organ Regenerat Surg, Toon, Ehime, Japan

[2] Ehime Univ, Dept Phys, Matsuyama, Ehime 790, Japan

[3] Ehime Univ, Dept Mat Sci & Engn, Matsuyama, Ehime 790, Japan

来源：

ANTICANCER RESEARCH | 2008年 / 28卷 / 1A期

关键词：

hyperthermia; thermotherapy; induction heating;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: This study investigated a novel approach for tumor ablation therapy using an alternating magnetic field combined with a sintered MgFe2O4 needle. This method differs from radiofrequency ablation (RFA) by dielectric heating with regard to the heating mechanism and improves some weak points of these conventional thermotherapies. Materials and Methods: Nude mice mimicking human breast cancer BT474 were treated using this method. The extent of tumor death was assessed after ablation. Results: Staining with hematoxylin and eosin showed gradual expansion of the pyknotic area until 48 h after ablation. Nicotinamide adenine dinucleotide diaphorase staining also showed complete tumor death by 48 h after treatment. The ablation area was well controlled and reablation was not necessary. The tumor could be completely controlled using this method without any risk of skin burn. Conclusion: This novel ablation therapy appeared to be more effective and less invasive for treatment of breast cancer treatment than RFA.

引用

页码：69 / 74

页数：6