Stress-response hormesis and aging: "That which Does Not Kill Us Makes Us Stronger"

被引:355
作者
Gems, David
Partridge, Linda [1 ]
机构
[1] UCL, Inst Healthy Ageing, London WC1E 6BT, England
基金
英国惠康基金;
关键词
D O I
10.1016/j.cmet.2008.01.001
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Hormesis refers to the beneficial effects of a treatment that at a higher intensity is harmful. In one form of hormesis, sublethal exposure to stressors; induces a response that results in stress resistance. The principle of stress-response hormesis is increasingly finding application in studies of aging, where hormetic increases in life span have been seen in several animal models.
引用
收藏
页码:200 / 203
页数:4
相关论文
共 22 条
  • [1] Alterations in xenobiotic metabolism in the long-lived Little mice
    Amador-Noguez, Daniel
    Dean, Adam
    Huang, Wendong
    Setchell, Kenneth
    Moore, David
    Darlington, Gretchen
    [J]. AGING CELL, 2007, 6 (04): : 453 - 470
  • [2] [Anonymous], 2006, HLTH RISKS EXP LOW L
  • [3] The functional costs and benefits of dietary restriction in Drosophila
    Burger, Joep M. S.
    Hwangbo, Dae Sung
    Corby-Harris, Vanessa
    Promislow, Daniel E. L.
    [J]. AGING CELL, 2007, 6 (01) : 63 - 71
  • [4] Hormesis: A highly generalizable and reproducible phenomenon with important implications for risk assessment
    Calabrese, EJ
    Baldwin, LA
    Holland, CD
    [J]. RISK ANALYSIS, 1999, 19 (02) : 261 - 281
  • [5] Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
    Clancy, DJ
    Gems, D
    Harshman, LG
    Oldham, S
    Stocker, H
    Hafen, E
    Leevers, SJ
    Partridge, L
    [J]. SCIENCE, 2001, 292 (5514) : 104 - 106
  • [6] Hormesis in Caenorhabditis elegans dauer-defective mutants
    Cypser, JR
    Johnson, TE
    [J]. BIOGERONTOLOGY, 2003, 4 (04) : 203 - 214
  • [7] Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity
    Cypser, JR
    Johnson, TE
    [J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2002, 57 (03): : B109 - B114
  • [8] Gibson GG., 2001, Introduction to Drug Metabolism
  • [9] The plasticity of aging: Insights from long-lived mutants
    Kenyon, C
    [J]. CELL, 2005, 120 (04) : 449 - 460
  • [10] Realized immune response is enhanced in long-lived puc and chico mutants but is unaffected by dietary restriction
    Libert, Sergiy
    Chao, Yufang
    Zwiener, Jessica
    Pletcher, Scott D.
    [J]. MOLECULAR IMMUNOLOGY, 2008, 45 (03) : 810 - 817