Significance of High-Risk Human Papillomavirus Testing for Atypical Glandular Cells on Cervical Cytology

被引：9

作者：

Komatsu, Hiroaki ^{[1
]}

Oishi, Tetsuro ^{[1
]}

Osaku, Daiken ^{[1
]}

Sawada, Mayumi ^{[1
]}

Kudoh, Akiko ^{[1
]}

Nonaka, Michiko ^{[1
]}

Chikumi, Jun ^{[1
]}

Sato, Shinya ^{[1
]}

Harada, Tasuku ^{[1
]}

机构：

[1] Tottori Univ, Dept Obstet & Gynecol, Sch Med, 36-1 Nishicho, Yonago, Tottori 6838504, Japan

来源：

ACTA CYTOLOGICA | 2018年 / 62卷 / 5-6期

关键词：

Atypical glandular cells; High-risk human papillomavirus; Human papillomavirus genotyping; Positive predictive value; Negative predictive value; ADENOCARCINOMA IN-SITU; SQUAMOUS-CELLS; WOMEN; MANAGEMENT; DIAGNOSIS; PREVALENCE; NEOPLASIA; SMEARS;

D O I：

10.1159/000490230

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objectives: The aim of this study was to evaluate the diagnostic significance of high-risk human papillomavirus (hrHPV) testing for managing women with atypical glandular cells (AGC) and to explore the distribution of hrHPV genotypes. Methods: We analyzed cytologic and histopathologic diagnoses in patients referred to our institution due to AGC or atypical squamous cells of undetermined significance (ASC-US). All patients underwent hrHPV testing and genotyping, and positive (PPV) and negative predictive values (NPV) for cervical intraepithelial neoplasia (CIN) 2 or worse [ CIN2+/adenocarcinoma in situ (AIS)+] were calculated. Results: Among 41 cases previously diagnosed with AGC, 22 (53%) were classified as CIN2+ (2 squamous cell carcinomas), whereas only 2 were AIS or adenocarcinoma. Twenty-seven (65.8%) cases in the AGC group were hrHPV positive. The most frequent genotypes in both the ASC-US and AGC groups were HPV16 and HPV52. The PPV of hrHPV testing for CIN2+/AIS+ was significantly higher in the AGC than in the ASC-US group (74.1 vs. 35.0%; p = 0.0005). The NPV for CIN2+/AIS+ was significantly lower in the AGC than in the ASC-US group (74.4 vs. 100%; p = 0.0441). Conclusion: In patients with AGC, both glandular and squamous lesions must be monitored. hrHPV testing is useful for detecting CIN2+/AIS+ in AGC. (C) 2018 S. Karger AG, Basel

引用

页码：405 / 410

页数：6

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