Prognostic nomogram for disease-specific survival of carcinoma ex pleomorphic adenoma of the salivary gland

被引：14

作者：

Hu, Yu-Hua ^{[1
]}

Li, Wei ^{[2
]}

Zhang, Chun-Ye ^{[1
]}

Xia, Rong-Hui ^{[1
]}

Tian, Zhen ^{[1
]}

Wang, Li-Zhen ^{[1
]}

Xie, Lu ^{[2
]}

Li, Jiang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Stomatol, Dept Oral Pathol,Peoples Hosp 9, Shanghai, Peoples R China

[2] Shanghai Acad Sci & Technol, Shanghai Ctr Bioinformat Technol, Translat Med Res Grp, Shanghai, Peoples R China

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2017年 / 39卷 / 12期

基金：

中国国家自然科学基金;

关键词：

carcinoma ex pleomorphic adenoma; clinicopathology malignant pleomorphic adenoma; nomogram; salivary gland; SQUAMOUS-CELL CARCINOMA; CLINICOPATHOLOGICAL ANALYSIS; CHINESE POPULATION; BREAST-CANCER; RECURRENCE; TUMORS;

D O I：

10.1002/hed.24908

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background: The purpose of this study was to establish an effective prognostic nomogram for carcinoma ex pleomorphic adenoma (Ca-ex-PA) of the salivary gland. Methods: The nomogram was based on a retrospective study on 223 patients who underwent surgical operation for Ca-ex-PA from 2001 to 2010. The predictive accuracy and discriminative ability of the nomogram were determined by concordance index (C-index) and calibration curve. The results were validated using bootstrap resampling and a prospective study on 111 patients operated on from 2011 to 2012. Results: On multivariate analysis of the primary cohort, independent factors for disease-specific survival (DSS) were age, tumor diameter, degree of capsule invasion, lymph node metastasis, and the interaction between tumor site and histological subtype, which were all selected into the nomogram. The C-index of the nomogram for predicting DSS was 0.90 and 0.86 in the primary cohort and validation cohort, respectively. Conclusion: The proposed nomogram resulted in more accurate prognostic predictions for patients with Ca-ex-PA.

引用

页码：2416 / 2424

页数：9

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