KCNQ2 and KCNQ3 potassium channel subunits: Molecular correlates of the M-channel

被引：1064

作者：

Wang, HS

Pan, ZM

Shi, WM

Brown, BS

Wymore, RS

Cohen, IS

Dixon, JE ^{[1
]}

McKinnon, D

机构：

[1] SUNY Stony Brook, Dept Physiol & Biophys, Inst Mol Cardiol, Stony Brook, NY 11794 USA

[2] SUNY Stony Brook, Dept Neurobiol & Behav, Stony Brook, NY 11794 USA

[3] Dupont Co, Pharmaceut, CNS Dis Res, Wilmington, DE 19880 USA

来源：

SCIENCE | 1998年 / 282卷 / 5395期

关键词：

D O I：

10.1126/science.282.5395.1890

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.

引用

页码：1890 / 1893

页数：4

共 30 条

[1] REDUCTION OF SPIKE FREQUENCY ADAPTATION AND BLOCKADE OF M-CURRENT IN RAT CA1 PYRAMIDAL NEURONS BY LINOPIRDINE (DUP-996), A NEUROTRANSMITTER RELEASE ENHANCER [J].