Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?

被引：98
作者：
Reizis, Boris [1 ]
Colonna, Marco [2 ]
Trinchieri, Giorgio [3 ]
Barrat, Franck [4 ]
Gilliet, Michel [5 ]
机构：
[1] Columbia Univ, Dept Microbiol & Immunol, New York, NY 10032 USA
[2] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
[3] NCI, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA
[4] Dynavax Technol Corp, Berkeley, CA 94710 USA
[5] Univ Hosp Lausanne CHUV, Dept Dermatol, CH-1011 Lausanne, Switzerland
来源：
NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 08期
基金：
美国国家卫生研究院;
关键词：
TRANSCRIPTION FACTOR E2-2; T-CELLS; ANTIGEN-PRESENTATION; INTERFERON; RESPONSES; SUBSETS; DNA;
D O I：
10.1038/nri3027
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Plasmacytoid dendritic cells (pDCs) were first described as interferon-producing cells and, for many years, their overlapping characteristics with both lymphocytes and classical dendritic cells (cDCs) created confusion over their exact ontogeny. In this Viewpoint article, Nature Reviews Immunology asks five leaders in the field to discuss their thoughts on the development and functions of pDCs - do these cells serve mainly as a major source of type I interferons or do they also make other important contributions to immune responses?
引用
收藏
页码：558 / U82
页数：9
相关论文
共 39 条
  • [1] Type I interferon dependence of plasmacytoid dendritic cell activation and migration
    Asselin-Paturel, C
    Brizard, G
    Chemin, K
    Boonstra, A
    O'Garra, A
    Vicari, A
    Trinchieri, G
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (07) : 1157 - 1167
  • [2] CX3CR1+ CD8α+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells
    Bar-On, Liat
    Birnberg, Tal
    Lewis, Kanako L.
    Edelson, Brian T.
    Bruder, Dunja
    Hildner, Kai
    Buer, Jan
    Murphy, Kenneth M.
    Reizis, Boris
    Jung, Steffen
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (33) : 14745 - 14750
  • [3] Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells
    Blasius, Amanda L.
    Arnold, Carrie N.
    Georgel, Philippe
    Rutschmann, Sophie
    Xia, Yu
    Lin, Pei
    Ross, Charles
    Li, Xiaohong
    Smart, Nora G.
    Beutler, Bruce
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (46) : 19973 - 19978
  • [4] Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: Dependency on antigen dose and differential toll-like receptor ligation
    Boonstra, A
    Asselin-Paturel, C
    Gilliet, M
    Crain, C
    Trinchieri, G
    Liu, YJ
    O'Garra, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (01) : 101 - 109
  • [5] Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
    Cao, Wei
    Bover, Laura
    Cho, Minkwon
    Wen, Xiaoxia
    Hanabuchi, Shino
    Bao, Musheng
    Rosen, David B.
    Wang, Yi-Hong
    Shaw, Joanne L.
    Du, Qiumei
    Li, Chun
    Arai, Naoko
    Yao, Zhengbin
    Lanier, Lewis L.
    Liu, Yong-Jun
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (07) : 1603 - 1614
  • [6] Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon
    Cervantes-Barragan, Luisa
    Zuest, Roland
    Weber, Friedernann
    Spiegel, Martin
    Lang, Karl S.
    Akira, Shizuo
    Thiel, Volker
    Ludewig, Burkhard
    [J]. BLOOD, 2007, 109 (03) : 1131 - 1137
  • [7] CHEHIMI J, 1989, IMMUNOLOGY, V68, P486
  • [8] Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas
    Cheong, Cheolho
    Matos, Ines
    Choi, Jae-Hoon
    Dandamudi, Durga Bhavani
    Shrestha, Elina
    Longhi, M. Paula
    Jeffrey, Kate L.
    Anthony, Robert M.
    Kluger, Courtney
    Nchinda, Godwin
    Koh, Hyein
    Rodriguez, Anthony
    Idoyaga, Juliana
    Pack, Maggi
    Velinzon, Klara
    Park, Chae Gyu
    Steinman, Ralph M.
    [J]. CELL, 2010, 143 (03) : 416 - 429
  • [9] Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development
    Cisse, Babacar
    Caton, Michele L.
    Lehner, Manfred
    Maeda, Takahiro
    Scheu, Stefanie
    Locksley, Richard
    Holmberg, Dan
    Zweier, Christiane
    den Hollander, Nicolette S.
    Kant, Sarina G.
    Holter, Wolfgang
    Rauch, Anita
    Zhuang, Yuan
    Reizis, Boris
    [J]. CELL, 2008, 135 (01) : 37 - 48
  • [10] Plasmacytoid dendritic cells in immunity
    Colonna, M
    Trinchieri, G
    Liu, YJ
    [J]. NATURE IMMUNOLOGY, 2004, 5 (12) : 1219 - 1226
1234