Predictive value of 1H MR spectroscopy and 18F-FDG PET/CT for local control of advanced oropharyngeal and hypopharyngeal squamous cell carcinoma receiving chemoradiotherapy: a prospective study

被引：1

作者：

Yeh, Chih-Hua ^{[1
,2
,3
]}

Lin, Gigin ^{[1
,2
,3
,4
,5
]}

Wang, Jiun-Jie ^{[3
,6
]}

Lin, Chien-Yu ^{[7
]}

Tsai, Shang-Yueh ^{[8
]}

Lin, Yu-Chun ^{[1
,2
,3
]}

Wu, Yi-Ming ^{[1
,2
,3
]}

Ko, Sheung-Fat ^{[3
,9
]}

Wang, Hung-Ming ^{[10
]}

Chan, Sheng-Chieh ^{[2
,11
]}

Yen, Tzu-Chen ^{[2
,11
]}

Liao, Chun-Ta ^{[12
]}

Ng, Shu-Hang ^{[1
,2
,3
]}

机构：

[1] Chang Gung Univ, Chang Gung Mem Hosp, Dept Med Imaging & Intervent, Taoyuan, Taiwan

[2] Chang Gung Mem Hosp, Mol Imaging Ctr, Taoyuan, Taiwan

[3] Chang Gung Univ, Dept Med Imaging & Radiol Sci, Taoyuan, Taiwan

[4] Chang Gung Mem Hosp, Inst Radiol Res, Clin Phenome Ctr, Taoyuan, Taiwan

[5] Chang Gung Mem Hosp, Inst Radiol Res, Imaging Core Lab, Taoyuan, Taiwan

[6] Chang Gung Mem Hosp, Dept Diagnost Radiol, Keelung, Taiwan

[7] Chang Gung Univ, Chang Gung Mem Hosp, Dept Radiat Oncol, Taoyuan, Taiwan

[8] Natl Chengchi Univ, Grad Inst Appl Phys, Taipei, Taiwan

[9] Chang Gung Mem Hosp, Dept Diagnost Radiol, Kaohsiung, Taiwan

[10] Chang Gung Univ, Chang Gung Mem Hosp, Dept Med Oncol, Taoyuan, Taiwan

[11] Chang Gung Univ, Chang Gung Mem Hosp, Dept Nucl Med, Taoyuan, Taiwan

[12] Chang Gung Univ, Chang Gung Mem Hosp, Dept Otorhinolaryngol Head & Neck Surg, Taoyuan, Taiwan

来源：

ONCOTARGET | 2017年 / 8卷 / 70期

关键词：

oropharyngeal cancer; hypopharyngeal cancer; MR spectroscopy; positron emission tomography; chemoradiotherapy; MAGNETIC-RESONANCE-SPECTROSCOPY; METABOLIC TUMOR VOLUME; STANDARDIZED UPTAKE VALUE; NECK-CANCER; IN-VIVO; TREATMENT RESPONSE; EXTRACRANIAL HEAD; CHEMORADIATION; GLUTAMINE; CHEMOTHERAPY;

D O I：

10.18632/oncotarget.23306

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: To determine whether pretreatment in vivo 1H magnetic resonance (MR) spectroscopy at 3 Tesla (T) and 18F-FDG PET/CT can offer predictive power regarding the local control of oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC) patients. Materials and Methods: H-1 MR spectroscopy was performed in addition to conventional MR imaging before definitive chemoradiotherapy in 58 patients with advanced OHSCC. The relationship of local control with the H-1 MR spectroscopy and F-18-FDG PET/CT parameters was analyzed. Results: With a median follow-up of 17.6 months, 13 (22.4%) patients exhibited local failure; whereas the remaining 45 achieved local control. Kaplan-Meier analysis identified age > 60 years, creatine level on MRS <= 6.02 mM, glutamine and glutamate (Glx) level on MRS > 3.31 mM, and total lesion glycolysis (TLG) on F-18-FDG PET/CT > 217.18 g/mL x mL as significant adverse predictors for 2-year local control. Multivariate Cox regression analysis showed that age (p=0.017), Glx level on MRS (p=0.021), and TLG on F-18-FDG PET/CT (p=0.028) retained their independent prognostic significance. A scoring system was constructed based on the sum of these three factors. We found that patients with scores of 2-3 had significantly poorer local control rates than patients with scores of 0-1 (33.3% versus 86.8%, p=0.003). Conclusion: We conclude that Glx on H-1 MR spectroscopy at 3 T was the independent prognostic factor for local control of OHSCC patients treated with chemoradiotherapy, and its combination with age and TLG may help identify a subgroup of patients at high risk for developing local failure.

引用

页码：115513 / 115525

页数：13

共 36 条

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