Inhibitory effects of Goishi tea against influenza virus infection

被引：10
作者：
Noguchi, Akane [1 ]
Hamauzu, Yasunori [1 ]
Yasui, Hisako [1 ]
机构：
[1] Shinshu Univ, Dept Sci Funct Foods, Grad Sch Agr, Nagano 3994598, Japan
来源：
FOOD SCIENCE AND TECHNOLOGY RESEARCH | 2008年 / 14卷 / 03期
关键词：
influenza virus; microbial fermented tea; polymeric phenol; inhibition;
D O I：
10.3136/fstr.14.277
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
We investigated the possible anti-influenza virus function of Goishi tea, which is a Japanese traditional microbial fermented tea, in in vitro and in vivo tests. We found that Goishi tea hot water extract (GTE) inhibited hemagglutination caused by influenza A/ Puerto Rico/ 8/ 34 (PR8, H1N1) and influenza A/ Guizhou/ 54/ 89 (Guizhou, H3N2) viruses, viral growth in Mardin-Darby canine kidney (MDCK) cells caused by PR8, and viral infection of mice caused by nasal inoculation of PR8. Furthermore, we investigated the functional fractions of GTE and found that a high-molecular-weight fraction of GTE inhibited viral adsorption to MDCK cells and that low-molecular-weight fractions inhibited subsequent stages of infection, such as viral invasion, genomic multiplication, and release, after adsorption. These results indicate that GTE exerts an inhibitory property against influenza virus infection by inhibiting various stages of infection.
引用
收藏
页码：277 / 284
页数：8
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