Prostate cancer and inflammation: the evidence

被引：478

作者：

Sfanos, Karen S. ^{[1
]}

De Marzo, Angelo M. ^{[2
,3
]}

机构：

[1] Sidney Kimmel Comprehens Canc Ctr, Dept Pathol, CRBII, Baltimore, MD 21231 USA

[2] Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Baltimore, MD 21231 USA

[3] Johns Hopkins Univ, Sch Med, Brady Urol Res Inst, Dept Urol, Baltimore, MD USA

来源：

HISTOPATHOLOGY | 2012年 / 60卷 / 01期

关键词：

cytokines; diet; infections; inflammation; proliferative inflammatory atrophy; prostate cancer; REGULATORY T-CELLS; SEXUALLY-TRANSMITTED INFECTIONS; CPG ISLAND HYPERMETHYLATION; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; POLYUNSATURATED FATTY-ACIDS; IN-SITU HYBRIDIZATION; PROPIONIBACTERIUM-ACNES; INTRAEPITHELIAL NEOPLASIA; CHLAMYDIA-TRACHOMATIS; ESCHERICHIA-COLI;

D O I：

10.1111/j.1365-2559.2011.04033.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chronic inflammation is now known to contribute to several forms of human cancer, with an estimated 20% of adult cancers attributable to chronic inflammatory conditions caused by infectious agents, chronic noninfectious inflammatory diseases and/or other environmental factors. Indeed, chronic in Ilammation is now regarded as an 'enabling characteristic' of human cancer. The aim of this review is to summarize the current literature on the evidence for a role for chronic inflammation in prostate cancer aetiology, with a specific focus on recent advances regarding the following: (i) potential stimuli for prostatic inflammation; (ii) prostate cancer immunobiology; (iii) inflammatory pathways and cytokines in prostate cancer risk and development; (iv) proliferative inflammatory atrophy (PIA) as a risk factor lesion to prostate cancer development; and (v) the role of nutritional or other anti-inflammatory compounds in reducing prostate cancer risk.

引用

页码：199 / 215

页数：17

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