Human Organoids and Organs-on-Chips for Addressing COVID-19 Challenges

被引:36
作者
Wang, Yaqing [1 ]
Wang, Peng [1 ]
Qin, Jianhua [1 ,2 ,3 ,4 ]
机构
[1] Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
[2] Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China
[3] Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China
[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
基金
中国博士后科学基金;
关键词
coronavirus disease 2019; human models in vitro; organoids; organs-on-chips; severe acute respiratory syndrome coronavirus 2; PLURIPOTENT STEM-CELL; A-CHIP; SARS-COV-2; NEUROTROPISM; BRAIN ORGANOIDS; CHOROID-PLEXUS; IN-VITRO; HEART; MODEL; INFECTION; PATHOGENESIS;
D O I
10.1002/advs.202105187
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an imminent threat to our lives. Although animal models and monolayer cell cultures are utilized for pathogenesis studies and the development of COVID-19 therapeutics, models that can more accurately reflect human-relevant responses to this novel virus are still lacking. Stem cell organoids and bioengineered organs-on-chips have emerged as two cutting-edge technologies used to construct biomimetic in vitro three-dimensional (3D) tissue or organ models. In this review, the key features of these two model systems that allow them to recapitulate organ physiology and function are introduced. The recent progress of these technologies for virology research is summarized and their utility in meeting the COVID-19 pandemic is highlighted. Future opportunities and challenges in the development of advanced human organ models and their potential to accelerate translational applications to provide vaccines and therapies for COVID-19 and other emerging epidemics are also discussed.
引用
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页数:17
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