Gastrointestinal tract specific gene GDDR inhibits the progression of gastric cancer in a TFF1 dependent manner

被引：19
作者：
Chu, Guanghui [1 ]
Qi, Shengbin [1 ]
Yang, Guodong [2 ]
Dou, Kefeng [3 ]
Du, Jianjun [1 ]
Lu, Zifan [2 ]
机构：
[1] Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian 710032, Peoples R China
[2] Fourth Mil Med Univ, Dept Biochem & Mol Biol, State Key Lab Canc Biol, Xian 710032, Peoples R China
[3] Fourth Mil Med Univ, Dept Hepatobiliary Surg, Xijing Hosp, Xian 710032, Peoples R China
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2012年 / 359卷 / 1-2期
基金：
美国国家科学基金会;
关键词：
GDDR; TFF1; Gastric cancer; Cell cycle; Proliferation; HELICOBACTER-PYLORI INFECTION; PANCREATIC SPASMOLYTIC POLYPEPTIDE; TREFOIL PROTEIN; INTESTINAL METAPLASIA; CARCINOGENESIS; EXPRESSION; CARCINOMA; DOMAIN; ASSOCIATION; SUPPRESSOR;
D O I：
10.1007/s11010-011-1030-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The novel gene GDDR, also named trefoil factor interactions 1, is abundantly expressed in human gastric epithelial cells but significantly down-regulated in gastric cancer. In this study, we first demonstrated that GDDR was specifically expressed in the gastrointestinal tract epithelium, while suppressed in gastric cancer cells. Forced expression of GDDR suppressed the tumor growth as shown by MTT and xenograft assay. siRNA mediated TFF1 inhibition nearly blocked the growth inhibitory role of GDDR. In summary, our study suggested that gastrointestinal tract specific gene GDDR might inhibit gastric cancer growth in a TFF1 dependent manner.
引用
收藏
页码：369 / 374
页数：6
相关论文
共 29 条
[11]   PANCREATIC SPASMOLYTIC POLYPEPTIDE (PSP) .1. PREPARATION AND INITIAL CHEMICAL CHARACTERIZATION OF A NEW POLYPEPTIDE FROM PORCINE PANCREAS [J].
JORGENSEN, KH ;
THIM, L ;
JACOBSEN, HE .
REGULATORY PEPTIDES, 1982, 3 (3-4) :207-219
[12]   Trefoil factor 1 is required for the commitment programme of mouse oxyntic epithelial progenitors [J].
Karam, SM ;
Tomasetto, C ;
Rio, MC .
GUT, 2004, 53 (10) :1408-1415
[13]  
Kirikoshi H, 2002, INT J ONCOL, V21, P655
[14]   Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein [J].
Lefebvre, O ;
Chenard, MP ;
Masson, R ;
Linares, J ;
Dierich, A ;
LeMeur, M ;
Wendling, C ;
Tomasetto, C ;
Chambon, P ;
Rio, MC .
SCIENCE, 1996, 274 (5285) :259-262
[15]   Expression of trefoil peptides (TFF1, TFF2, and TFF3) in gastric carcinomas, intestinal metaplasia, and non-neoplastic gastric tissues [J].
Leung, WK ;
Yu, J ;
Chan, FKL ;
To, KF ;
Chan, MWY ;
Ebert, MPA ;
Ng, EKW ;
Chung, SCS ;
Malfertheiner, P ;
Sung, JJY .
JOURNAL OF PATHOLOGY, 2002, 197 (05) :582-588
[16]   Tissue localization of human trefoil factors 1, 2, and 3 [J].
Madsen, Jens ;
Nielsen, Ole ;
Tornoe, Ida ;
Thim, Lars ;
Holmskov, Uffe .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2007, 55 (05) :505-513
[17]   The trefoil factor interacting protein TFIZ1 binds the trefoil protein TFF1 preferentially in normal gastric mucosal cells but the co-expression of these proteins is deregulated in gastric cancer [J].
May, Felicity E. B. ;
Griffin, S. Michael ;
Westley, Bruce R. .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2009, 41 (03) :632-640
[18]   HELICOBACTER-PYLORI INFECTION AND GASTRIC-CARCINOMA AMONG JAPANESE-AMERICANS IN HAWAII [J].
NOMURA, A ;
STEMMERMANN, GN ;
CHYOU, PH ;
KATO, I ;
PEREZPEREZ, GI ;
BLASER, MJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (16) :1132-1136
[19]   HELICOBACTER-PYLORI INFECTION AND THE RISK OF GASTRIC-CARCINOMA [J].
PARSONNET, J ;
FRIEDMAN, GD ;
VANDERSTEEN, DP ;
CHANG, Y ;
VOGELMAN, JH ;
ORENTREICH, N ;
SIBLEY, RK .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (16) :1127-1131
[20]   Global analysis of the human gastric epithelial transcriptome altered by Helicobacter pylori eradication in vivo [J].
Resnick, M. B. ;
Sabo, E. ;
Meitner, P. A. ;
Kim, S. S. ;
Cho, Y. ;
Kim, H. K. ;
Tavares, R. ;
Moss, S. F. .
GUT, 2006, 55 (12) :1717-1724
123