An age-associated decrease in the frequency of C4B*Q0 indicates that null alleles of complement may affect health or survival

被引：18

作者：

Arason, GJ

Bodvarsson, S

Sigurdarson, SP

Sigurdarson, TP

Sigurdsson, G

Thorgeirsson, G

Gudmundsson, S

Kramer, J

Füst, G

机构：

[1] Landspitali Univ Hosp, Inst Lab Med, Dept Immunol, LSH Hringbraut, IS-101 Reykjavik, Iceland

[2] Landspitali Univ Hosp, Dept Med, LSH Hringbraut, IS-101 Reykjavik, Iceland

[3] Natl Blood Bank, IS-101 Reykjavik, Iceland

[4] St Johns Hosp, Cent Lab, Budapest, Hungary

[5] Hungarian Acad Sci, Res Grp Metab & Atherosclerosis, Budapest, Hungary

[6] Semmelweis Univ, Dept Med 3, H-1085 Budapest, Hungary

来源：

APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS | 2003年 / 1010卷

关键词：

coronary artery disease; Iceland; Hungary; C4B*Q0;

D O I：

10.1196/annals.1299.091

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We studied the distribution of complement C4, C3, and factor B allotypes in 423 healthy Icelandic subjects from 17 to 89 years of age. A marked decrease was observed in the carrier frequency of variant alleles of complement C4B (C4B*Q0) and C3 (C3*F). These results confirm our previous observations on Hungarian subjects and suggest a negative effect of C4B*Q0 on health or survival.

引用

页码：496 / 499

页数：4

共 6 条

[1] Increased frequency of C4B null alleles in Icelandic patients with coronary disease [J].