Persisting SARS-CoV-2 viraemia after rituximab therapy: two cases with fatal outcome and a review of the literature

被引：118

作者：

Tepasse, Phil-Robin ^{[1
]}

Hafezi, Wali ^{[2
]}

Lutz, Mathias ^{[3
]}

Kuehn, Joachim ^{[2
]}

Wilms, Christian ^{[1
]}

Wiewrodt, Rainer ^{[3
]}

Sackarnd, Jan ^{[4
]}

Keller, Martin ^{[5
]}

Schmidt, Hartmut H. ^{[1
]}

Vollenberg, Richard ^{[1
]}

机构：

[1] Univ Hosp Muenster, Dept Gastroenterol & Hepatol, Sect Infect Dis, Munster, Germany

[2] Univ Hosp Muenster, Inst Virol, Munster, Germany

[3] Univ Hosp Muenster, Dept Hematol & Oncol, Munster, Germany

[4] Univ Hosp Muenster, Dept Cardiol & Angiol, Munster, Germany

[5] Univ Hosp Muenster, Dept Anesthesiol Intens Care Med & Pain Therapy, Munster, Germany

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2020年 / 190卷 / 02期

关键词：

SARS-CoV-2; COVID-19; rituximab; viraemia; pneumonia;

D O I：

10.1111/bjh.16896

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

SARS-CoV-2 infection can cause severe pneumonia (COVID-19). There is evidence that patients with comorbidities are at higher risk of a severe disease course. The role of immunosuppression in the disease course is not clear. In the present report, we first describe two cases of persisting SARS-CoV-2 viraemia with fatal outcome in patients after rituximab therapy.

引用

页码：185 / 188

页数：4

共 14 条

[1] Tocilizumab for the treatment of severe coronavirus disease 2019 [J].

Alattar, Rand ;

Ibrahim, Tawheeda B. H. ;

Shaar, Shahd H. ;

Abdalla, Shiema ;

Shukri, Kinda ;

Daghfal, Joanne N. ;

Khatib, Mohamed Y. ;

Aboukamar, Mohamed ;

Abukhattab, Mohamed ;

Alsoub, Hussam A. ;

Almaslamani, Muna A. ;

Omrani, Ali S. .

JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (10) :2042-2049

[2] Replication of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E is inhibited by the drug FK506 [J].

Carbajo-Lozoya, Javier ;

Mueller, Marcel A. ;

Kallies, Stephan ;

Thiel, Volker ;

Drosten, Christian ;

von Brunn, Albrecht .

VIRUS RESEARCH, 2012, 165 (01) :112-117

[3] Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (Publication with Expression of Concern) [J].

Corman, Victor M. ;

Landt, Olfert ;

Kaiser, Marco ;

Molenkamp, Richard ;

Meijer, Adam ;

Chu, Daniel K. W. ;

Bleicker, Tobias ;

Bruenink, Sebastian ;

Schneider, Julia ;

Schmidt, Marie Luisa ;

Mulders, Daphne G. J. C. ;

Haagmans, Bart L. ;

van der Veer, Bas ;

van den Brink, Sharon ;

Wijsman, Lisa ;

Goderski, Gabriel ;

Romette, Jean-Louis ;

Ellis, Joanna ;

Zambon, Maria ;

Peiris, Malik ;

Goossens, Herman ;

Reusken, Chantal ;

Koopmans, Marion P. G. ;

Drosten, Christian .

EUROSURVEILLANCE, 2020, 25 (03) :23-30

[4] Novel Coronavirus-19 (COVID-19) in the immunocompromised transplant recipient: #Flatteningthecurve [J].

Fishman, Jay A. ;

Grossi, Paolo A. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2020, 20 (07) :1765-1767

[5] The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2 [J].

Gorbalenya, Alexander E. ;

Baker, Susan C. ;

Baric, Ralph S. ;

de Groot, Raoul J. ;

Drosten, Christian ;

Gulyaeva, Anastasia A. ;

Haagmans, Bart L. ;

Lauber, Chris ;

Leontovich, Andrey M. ;

Neuman, Benjamin W. ;

Penzar, Dmitry ;

Perlman, Stanley ;

Poon, Leo L. M. ;

Samborskiy, Dmitry V. ;

Sidorov, Igor A. ;

Sola, Isabel ;

Ziebuhr, John .

NATURE MICROBIOLOGY, 2020, 5 (04) :536-544

[6] Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [J].

Huang, Chaolin ;

Wang, Yeming ;

Li, Xingwang ;

Ren, Lili ;

Zhao, Jianping ;

Hu, Yi ;

Zhang, Li ;

Fan, Guohui ;

Xu, Jiuyang ;

Gu, Xiaoying ;

Cheng, Zhenshun ;

Yu, Ting ;

Xia, Jiaan ;

Wei, Yuan ;

Wu, Wenjuan ;

Xie, Xuelei ;

Yin, Wen ;

Li, Hui ;

Liu, Min ;

Xiao, Yan ;

Gao, Hong ;

Guo, Li ;

Xie, Jungang ;

Wang, Guangfa ;

Jiang, Rongmeng ;

Gao, Zhancheng ;

Jin, Qi ;

Wang, Jianwei ;

Cao, Bin .

LANCET, 2020, 395 (10223) :497-506

[7] Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission [J].

Hui, David S. ;

Azhar, Esam I. ;

Kim, Yae-Jean ;

Memish, Ziad A. ;

Oh, Myoung-don ;

Zumla, Alimuddin .

LANCET INFECTIOUS DISEASES, 2018, 18 (08) :E217-E227

[8] COVID-19 cytokine storm: the interplay between inflammation and coagulation [J].

Jose, Ricardo J. ;

Manuel, Ari .

LANCET RESPIRATORY MEDICINE, 2020, 8 (06) :E46-E47

[9] Progressive Multifocal Leukoencephalopathy after Ibrutinib Therapy for Chronic Lymphocytic Leukemia [J].

Lutz, Mathias ;

Schulze, Arik B. ;

Rebber, Elisabeth ;

Wiebe, Stefanie ;

Zoubi, Tarek ;

Grauer, Oliver M. ;

Kessler, Torsten ;

Kerkhoff, Andrea ;

Lenz, Georg ;

Berdel, Wolfgang E. .

CANCER RESEARCH AND TREATMENT, 2017, 49 (02) :548-552

[10] RETRACTED: Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19 (Publication with Expression of Concern. See vol. 382, pg. 2464, 2020) (Retracted article. See vol. 382, pg. 2582, 2020) [J].

Mehra, Mandeep R. ;

Desai, Sapan S. ;

Kuy, SreyRam ;

Henry, Timothy D. ;

Patel, Amit N. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (25)

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