Notch to remember

被引：70

作者：

Costa, RM

Drew, C

Silva, AJ

机构：

[1] Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90095 USA

来源：

TRENDS IN NEUROSCIENCES | 2005年 / 28卷 / 08期

关键词：

D O I：

10.1016/j.tins.2005.05.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Some of the signaling molecules required for formation of long-term memories are involved primarily in adult brain function, but others participate in a variety of other biological processes. The Notch signaling pathway, which is important for cell fate specification and differentiation in various systems, is also active in the mature brain. Here, we review evidence from recent studies indicating that Notch signaling is required for formation of long-term memories, and discuss possible memory processes modulated by this pathway. We also consider the possible involvement of Notch signaling in cognitive disorders.

引用

页码：429 / 435

页数：7

共 76 条

[1] RAPID REMODELING OF AXONAL ARBORS IN THE VISUAL-CORTEX [J].