Dual role of NF-κB in apoptosis of THP-1 cells during treatment with etoposide and lipopolysaccharide

被引：10

作者：

Sato, K ^{[1
]}

Taniguchi, T ^{[1
]}

Suzuki, M ^{[1
]}

Shinohara, F ^{[1
]}

Takada, H ^{[1
]}

Rikiishi, H ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Dent, Dept Microbiol & Immunol, Aoba Ku, Sendai, Miyagi 9808575, Japan

来源：

LEUKEMIA RESEARCH | 2004年 / 28卷 / 01期

基金：

日本学术振兴会;

关键词：

apoptosis; THP-1; cells; lipopolysaccharide; etoposide; NF-kappa B; Bax; XIAP;

D O I：

10.1016/S0145-2126(03)00127-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One of the mechanisms repressing apoptosis in tumor cells can involve the expression of anti-apoptotic NF-kappaB target genes. In this study, we demonstrated that a potent NF-kappaB inhibitor, Not-tosyl-L-lysinyl chloromethyl ketone (TLCK), inhibits apoptosis of THP-1 cells triggered by etoposide (VP16), and actinomycin D (ACT D) or cycloheximide inhibits apoptosis. However, persistent activation of NF-kappaB by lipopolysaccharide (LPS) led to the survival of leukemic cells against VP16-induced apoptosis. Thus, the molecular events (Bax/X-chromosome-linked IAP (XIAP)) occurring downstream of NF-kappaB activation during VP16 and/or LPS stimulation may become important to understand the multiple effects of NF-kappaB. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：63 / 69

页数：7

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