Synthesis and Biological Evaluation of Novel Betulin Derivatives with Aromatic Hydrazone Side Chain as Potential Anticancer Agents

被引：8

作者：

Wang, Jiafeng ^{[1
]}

Wu, Jiale ^{[1
]}

Han, Yinglong ^{[1
]}

Zhang, Jie ^{[1
]}

Lin, Yu ^{[1
]}

Wang, Haijun ^{[1
]}

Wang, Jing ^{[1
]}

Bu, Ming ^{[1
]}

机构：

[1] Qiqihar Med Univ, Coll Pharm, Qiqihar 161006, Peoples R China

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2022年 / 33卷 / 03期

关键词：

betulin derivatives; hydrazone; heterocycles; antitumor; apoptosis; IN-VITRO; HETEROCYCLES; ACID;

D O I：

10.21577/0103-5053.20210140

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel betulin-28-hydrazone derivatives (7a-7o) were synthesized. All compounds were evaluated for their in vitro cytotoxicities in four human carcinoma cells (HepG2, MCF-7, HCT-116 and A549). Among them, compound 7l displayed the most potent cytotoxicity with an IC50 (concentration of the tested compound that inhibits 50% of cell growth) value of 7.37 +/- 0.38 mu M against MCF-7 cells. The preliminary cellular mechanism studies indicated that compound 7l could induce MCF-7 cells apoptosis. The above findings indicated that compound 7l may be used as a lead compound for antitumor agents with improved efficacy.

引用

页码：227 / +

页数：41

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