Refractory Pediatric Nonrhabdomyosarcoma Soft Tissue Sarcoma Associated With Ectopic Production of Beta hCG and Hypercalcemia Induced by PTHrP

被引：8

作者：

Inoue, Nami ^{[1
]}

Watanabe, Hiroyoshi ^{[1
]}

Takehara, Hiroo ^{[2
]}

Hamazaki, Minoru ^{[3
]}

Kagami, Shoji ^{[1
]}

机构：

[1] Tokushima Univ Hosp, Dept Pediat, Tokushima 7708503, Japan

[2] Tokushima Univ Hosp, Dept Pediat Surg & Pediat Endosurg, Tokushima 7708503, Japan

[3] Shizuoka Childrens Hosp, Dept Pathol, Shizuoka, Japan

来源：

PEDIATRIC BLOOD & CANCER | 2011年 / 57卷 / 07期

关键词：

beta-human chorionic gonadotropin; hypercalcemia; paraneoplastic manifestation; soft tissue sarcoma; HORMONE-RELATED PROTEIN; LEIOMYOSARCOMA; CANCER; CHILDREN; TUMOR;

D O I：

10.1002/pbc.23271

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 3-month-old male with a mass on the right side of his back was admitted to our hospital. The tumor was a pathologically high-grade nonrhabdomyosarcoma soft tissue sarcoma (NRSTS). Treatment included subtotal tumor resection followed by chemotherapy. Elevation of serum beta hCG and hypercalcemia with detection of PTHrP was associated with tumor progression. The tumor was refractory to multiagent chemotherapy, and the patient died of the disease at 22 months of age. This case is novel in demonstrating a beta hCG secreting refractory NRSTS. Pediatr Blood Cancer 2011;57:1244-1246. (C) 2011 Wiley Periodicals, Inc.

引用

页码：1244 / 1246

页数：3

共 22 条

[1]

Bode HH, 2008, J PEDIATR ENDOCR MET, V21, P275

[2] Localized unresectable non-rhabdo soft tissue sarcomas of the extremities in pediatric age results from the Italian studies [J].

Cecchetto, G ;

Alaggio, R ;

Dall'Igna, P ;

Bisogno, G ;

Ferrari, A ;

Gigante, C ;

Casanova, M ;

Sotti, G ;

Zanetti, I ;

Carli, M .

CANCER, 2005, 104 (09) :2006-2012

[3] Immunohistochemistry in the diagnosis of soft tissue tumours [J].

Coindre, JM .

HISTOPATHOLOGY, 2003, 43 (01) :1-16

[4] Intergroup rhabdomyosarcoma study-IV: Results for patients with nonmetastatic disease [J].

Crist, WM ;

Anderson, JR ;

Meza, JL ;

Fryer, C ;

Raney, RB ;

Ruymann, FB ;

Breneman, J ;

Qualman, SJ ;

Wiener, E ;

Wharam, M ;

Lobe, T ;

Webber, B ;

Maurer, HM ;

Donaldson, SS .

JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (12) :3091-3102

[5] NEONATAL SOFT-TISSUE SARCOMAS - THE INFLUENCE OF PATHOLOGY ON TREATMENT AND SURVIVAL [J].

DILLON, PW ;

WHALEN, TV ;

AZIZKHAN, RG ;

HAASE, GM ;

CORAN, AG ;

KING, DR ;

SMITH, M .

JOURNAL OF PEDIATRIC SURGERY, 1995, 30 (07) :1038-1041

[6]

Dobrowolski Z. F., 1994, International Urology and Nephrology, V26, P301, DOI 10.1007/BF02768213

[7] Parathyroid hormone-related protein confers chemoresistance by blocking apoptosis signaling via death receptors and mitochondria [J].

Gagiannis, Sarah ;

Mueller, Martina ;

Uhlemann, Sebastian ;

Koch, Andreas ;

Melino, Gerry ;

Krammer, Peter H. ;

Nawroth, Peter P. ;

Brune, Maik ;

Schilling, Tobias .

INTERNATIONAL JOURNAL OF CANCER, 2009, 125 (07) :1551-1557

[8] Ectopic hCGβ expression by epithelial cancer:: Malignant behaviour, metastasis and inhibition of tumor cell apoptosis [J].

Iles, R. K. .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2007, 260 :264-270

[9] Hypercalcemia in children with rhabdomyosarcoma [J].

Kawasaki, H ;

Takayama, J ;

Nagasaki, K ;

Yamaguchi, K ;

Ohira, M .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 1998, 20 (04) :327-329

[10] Retroperitoneal leiomyosarcoma and enlarged epididymis associated with a positive pregnancy test [J].

Mansi, IA ;

Ashley, I ;

Glezerov, V .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2002, 324 (02) :104-105

← 1 2 3 →