Cold stress induced morphological microglial activation and increased IL-1β expression in astroglial cells in rat brain

被引：42

作者：

Sugama, Shuei ^{[1
]}

Takenouchi, Takato ^{[2
]}

Fujita, Masayo ^{[3
]}

Kitani, Hiroshi ^{[2
]}

Hashimoto, Makoto ^{[3
]}

机构：

[1] Nippon Med Sch, Dept Physiol, Bunkyo Ku, Tokyo 1138602, Japan

[2] Natl Inst Agrobiol Sci, Transgen Anim Res Ctr, Tsukuba, Ibaraki 3058634, Japan

[3] Tokyo Metropolitan Inst Neurosci, Lab Chem & Metab, Tokyo 1838526, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2011年 / 233卷 / 1-2期

关键词：

Cold stress; Microglia; Interleukin-1; beta; Astroglia; Hippocampus; Hypothalamus; CNS; CORTICOTROPIN-RELEASING FACTOR; HIPPOCAMPAL CA1 REGION; PARKINSONS-DISEASE; INTERLEUKIN-1; RECEPTOR; REACTIVE MICROGLIA; ALZHEIMERS-DISEASE; SUBSTANTIA-NIGRA; IN-VITRO; NEURONS; INFLAMMATION;

D O I：

10.1016/j.jneuroim.2010.11.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present study investigated the possible impact of cold stress on the immune functions of the brain. Wistar rats were exposed to 4 degrees C for 2 h prior to analysis of immunohistochemical analysis of OX-42 and IL-1 beta, which are markers of microglia and inflammation, respectively. Exposure to cold stress induced morphological microglial activation in as early as 30 min, and the activation lasted up to 2 h following the stress. In addition, increased IL-1 beta-immunoreactivity was detected in the hippocampus and hypothalamus. However, IL-1 beta was not co-localized with microglia, and was predominantly expressed in astroglia. The present study provides the first evidence that cold stress contributes to neuro-immunomodulation in the brain through microglial activation and expression of IL-1 beta in astroglia. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：29 / 36

页数：8

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