Effects of α-Lipoic Acid Supplementation on Malondialdehyde Contents and Superoxide Dismutase in Rat Skeletal Muscles

被引:2
作者
Kim, Wan-Jae [1 ]
Kang, Jun-Yong [2 ]
Kwon, Dae-Keun [2 ]
Song, Young-Ju [2 ]
Lee, Kwang-Ho [1 ]
机构
[1] Konkuk Univ, Dept Biotechnol, Chungju 380701, Chungbuk, South Korea
[2] Sunmoon Univ, Lab Sports Nutr, Asan 336708, Chungnam, South Korea
关键词
alpha-lipoic acid; malondialdehyde; superoxide dismutase; skeletal muscle; OXIDATIVE STRESS; VITAMIN-E; EXERCISE; METABOLISM; FLOW;
D O I
10.1007/s10068-011-0154-y
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
This study investigated the effects of a-lipoic acid (ALA) supplementation on the malondialdehyde (MDA) contents and superoxide dismutase (SOD) protein expression in rat skeletal muscles under non-exercising condition. Fourteen Sprague-Dawley male rats at the age of 6 weeks were randomly divided into 2 groups CS, (normal diet group, n=7) and AS (0.5% ALA supplemented diet group, n=7), and keep non-exercising condition for 4 weeks. The muscle MDA concentration of the AS group was significantly lower than that of the CS group in the both soleus and extensor digitorum longus muscles. The expressions of Cu/Zn-SOD and Mn-SOD proteins in the soleus muscle were significantly higher in the AS group than that in the CS group. From these results, ALA supplementation under non-exercising condition had a role in increasing of antioxidant enzymes in skeletal muscle types of rats.
引用
收藏
页码:1133 / 1136
页数:4
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