Effects of α-Lipoic Acid Supplementation on Malondialdehyde Contents and Superoxide Dismutase in Rat Skeletal Muscles

被引：2

作者：

Kim, Wan-Jae ^{[1
]}

Kang, Jun-Yong ^{[2
]}

Kwon, Dae-Keun ^{[2
]}

Song, Young-Ju ^{[2
]}

Lee, Kwang-Ho ^{[1
]}

机构：

[1] Konkuk Univ, Dept Biotechnol, Chungju 380701, Chungbuk, South Korea

[2] Sunmoon Univ, Lab Sports Nutr, Asan 336708, Chungnam, South Korea

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2011年 / 20卷 / 04期

关键词：

alpha-lipoic acid; malondialdehyde; superoxide dismutase; skeletal muscle; OXIDATIVE STRESS; VITAMIN-E; EXERCISE; METABOLISM; FLOW;

D O I：

10.1007/s10068-011-0154-y

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

This study investigated the effects of a-lipoic acid (ALA) supplementation on the malondialdehyde (MDA) contents and superoxide dismutase (SOD) protein expression in rat skeletal muscles under non-exercising condition. Fourteen Sprague-Dawley male rats at the age of 6 weeks were randomly divided into 2 groups CS, (normal diet group, n=7) and AS (0.5% ALA supplemented diet group, n=7), and keep non-exercising condition for 4 weeks. The muscle MDA concentration of the AS group was significantly lower than that of the CS group in the both soleus and extensor digitorum longus muscles. The expressions of Cu/Zn-SOD and Mn-SOD proteins in the soleus muscle were significantly higher in the AS group than that in the CS group. From these results, ALA supplementation under non-exercising condition had a role in increasing of antioxidant enzymes in skeletal muscle types of rats.

引用

页码：1133 / 1136

页数：4

共 18 条

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