Prevention and treatment of relapse after stem cell transplantation by cellular therapies

被引：14

作者：

Falkenburg, Fred ^{[1
]}

Ruggiero, Eliana ^{[2
]}

Bonini, Chaira ^{[2
,3
]}

Porter, David ^{[4
]}

Miller, Jeff ^{[5
]}

Malard, Floran ^{[6
]}

Mohty, Mohamad ^{[6
]}

Kroger, Nicolaus ^{[7
]}

Kolb, Hans Jochem ^{[8
]}

机构：

[1] Leiden Univ, Dept Hematol, Med Ctr, Leiden, Netherlands

[2] Ist Sci San Raffaele, Div Immunol Transplantat & Infect Dis, Expt Hematol Unit, Milan, Italy

[3] Univ Vita Salute San Raffaele, Milan, Italy

[4] Univ Penn, Div Hematol Oncol, Blood & Marrow Program, Perelman Sch Med, Philadelphia, PA 19104 USA

[5] Univ Minnesota, Blood & Marrow Transplant Program, Minneapolis, MN USA

[6] St Antoine Hosp, AP HP, Hematol Dept, Paris, France

[7] Univ Med Ctr Hamburg Eppendorf, Dept Stem Cell Transplantat, Hamburg, Germany

[8] Kolb Consulting, Munich, Germany

来源：

BONE MARROW TRANSPLANTATION | 2019年 / 54卷 / 01期

关键词：

NATURAL-KILLER-CELLS; BONE-MARROW-TRANSPLANTATION; DONOR LYMPHOCYTE INFUSION; IN-VIVO EXPANSION; RECEPTOR T-CELLS; REDUCED-INTENSITY; NK CELLS; ACUTE-LEUKEMIA; ALLOGENEIC TRANSPLANTATION; CANCER REGRESSION;

D O I：

10.1038/s41409-018-0227-0

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Despite recent advances in reducing therapy-related mortality after allogeneic stem cell transplantation (alloSCT) relapse remains the major cause of treatment failure and little progress has been achieved in the last decades. At the 3rd International Workshop on Biology, Prevention, and Treatment of Relapse held in Hamburg/ Germany in November 2016 international experts presented and discussed recent developments in the field. Here, the potential of cellular therapies including unspecific and specific T cells, genetically modified T cells, CAR-T cells, NK-cells, and second allografting in prevention and treatment of relapse after alloSCT are summarized.

引用

页码：26 / 34

页数：9

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