In this paper, we consider the asymptotic behavior of positive solutions of the biharmonic equation Delta(2)u = u(p) in B-2\{0) with an isolated singularity, where the punctured ball B-2\{0} subset of R-n with n > 5 and p > (n + 4)/(n - 4). We classify isolated singularities of positive solutions and describe the asymptotic behavior of positive singular solutions without the sign assumption for -Delta u. (C) 2021 Elsevier Ltd. All rights reserved.