Controlled In Vivo Swimming of a Swarm of Bacteria-Like Microrobotic Flagella

被引：353

作者：

Servant, Ania ^{[1
,2
,3
]}

Qiu, Famin ^{[4
]}

Mazza, Mariarosa ^{[1
,2
,3
]}

Kostarelos, Kostas ^{[1
,2
,3
]}

Nelson, Bradley J. ^{[4
]}

机构：

[1] Univ Manchester, Fac Med & Human Sci, Nanomed Lab, Manchester M13 9PT, Lancs, England

[2] Univ Manchester, Natl Graphene Inst, Manchester M13 9PT, Lancs, England

[3] UCL, UCL Fac Life Sci, London WC1N 1AX, England

[4] ETH, Inst Robot & Intelligent Syst, CH-8092 Zurich, Switzerland

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 19期

基金：

欧洲研究理事会; 英国工程与自然科学研究理事会;

关键词：

delivery; nanomedicine; microrobots; targeting; wireless navigation; FABRICATION; MICROMACHINES; NANOPARTICLES; PROPULSION; DRIVEN;

D O I：

10.1002/adma.201404444

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In vivo imaging and actuation of a swarm of magnetic helical microswimmers by external magnetic fields (less than 10 mT) in deep tissue is demonstrated for the first time. This constitutes a major milestone in the field, yielding a generation of micrometer-scale transporters with numerous applications in biomedicine including synthetic biology, assisted fertilization, and drug/gene delivery. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2981 / 2988

页数：8

共 51 条

[1] How Should Microrobots Swim? [J].

Abbott, Jake J. ;

Peyer, Kathrin E. ;

Lagomarsino, Marco Cosentino ;

Zhang, Li ;

Dong, Lixin ;

Kaliakatsos, Ioannis K. ;

Nelson, Bradley J. .

INTERNATIONAL JOURNAL OF ROBOTICS RESEARCH, 2009, 28 (11-12) :1434-1447

[2] Polymeric coating of surface modified nitinol stent with POSS-nanocomposite polymer [J].

Bakhshi, Raheleh ;

Darbyshire, Arnold ;

Evans, James Eaton ;

You, Zhong ;

Lu, Jian ;

Seifalian, Alexander M. .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2011, 86 (01) :93-105

[3] Nanomedicine: Magnetic Nanoparticles and their Biomedical Applications [J].

Banerjee, R. ;

Katsenovich, Y. ;

Lagos, L. ;

McIintosh, M. ;

Zhang, X. ;

Li, C. -Z. .

CURRENT MEDICINAL CHEMISTRY, 2010, 17 (27) :3120-3141

[4] Design methodology for biomimetic propulsion of miniature swimming robots [J].

Behkam, B ;

Sitti, M .

JOURNAL OF DYNAMIC SYSTEMS MEASUREMENT AND CONTROL-TRANSACTIONS OF THE ASME, 2006, 128 (01) :36-43

[5] Remotely powered self-propelling particles and micropumps based on miniature diodes [J].

Chang, Suk Tai ;

Paunov, Vesselin N. ;

Petsev, Dimiter N. ;

Velev, Orlin D. .

NATURE MATERIALS, 2007, 6 (03) :235-240

[6] Endocytosis of PEGylated Agents Enhances Cancer Imaging and Anticancer Efficacy [J].

Chuang, Kuo-Hsiang ;

Wang, Hsin-Ell ;

Chen, Fang-Ming ;

Tzou, Shey-Cherng ;

Cheng, Chiu-Min ;

Chang, Ya-Chen ;

Tseng, Wei-Lung ;

Shiea, Jentaie ;

Lin, Shiu-Ru ;

Wang, Jaw-Yuan ;

Chen, Bing-Mae ;

Roffler, Steve R. ;

Cheng, Tian-Lu .

MOLECULAR CANCER THERAPEUTICS, 2010, 9 (06) :1903-1912

[7] Mechanised nanoparticles for drug delivery [J].

Coti, Karla K. ;

Belowich, Matthew E. ;

Liong, Monty ;

Ambrogio, Michael W. ;

Lau, Yuen A. ;

Khatib, Hussam A. ;

Zink, Jeffrey I. ;

Khashab, Niveen M. ;

Stoddart, J. Fraser .

NANOSCALE, 2009, 1 (01) :16-39

[8] An untethered, electrostatic, globally controllable MEMS micro-robot [J].

Donald, BR ;

Levey, CG ;

McGray, CD ;

Paprotny, I ;

Rus, D .

JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2006, 15 (01) :1-15

[9] Magnetically actuated propulsion at low Reynolds numbers: towards nanoscale control [J].

Fischer, Peer ;

Ghosh, Ambarish .

NANOSCALE, 2011, 3 (02) :557-563

[10]

Freitas Robert A Jr, 2005, Int J Surg, V3, P243, DOI 10.1016/j.ijsu.2005.10.007

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