Intestinal integrity and Akkermansia muciniphila, a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly

被引：575

作者：

Collado, M. Carmen

Derrien, Muriel

Isolauri, Erika

机构：

[1] Univ Tartu, Funct Foods Forum, FI-20520 Turku, Finland

[2] Univ Wageningen, Microbiol Lab, NL-6703 HB Wageningen, Netherlands

[3] Turku Univ, Dept Pediat, FI-20014 Turku, Finland

[4] Univ Helsinki, Dept Vet Basic Sci, FI-00014 Helsinki, Finland

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2007年 / 73卷 / 23期

关键词：

D O I：

10.1128/AEM.01477-07

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Fluorescence in situ hybridization and real-time PCR analysis targeting the 16S rRNA gene of Akkermansia muciniphila were performed to determine its presence in the human intestinal tract. These techniques revealed that an A. muciniphila-like bacterium is a common member of the human intestinal tract and that its colonization starts in early life and develops within a year to a level close to that observed in adults (10(8) cells/g) but decreases (P < 0.05) in the elderly.

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页码：7767 / 7770

页数：4

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