Chronic immune response dysregulation in MDS pathogenesis

被引：161

作者：

Barreyro, Laura ^{[1
]}

Chlon, Timothy M. ^{[1
,2
]}

Starczynowski, Daniel T. ^{[1
,2
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Expt Hematol & Canc Biol, Cincinnati, OH 45229 USA

[2] Univ Cincinnati, Dept Canc Biol, Cincinnati, OH USA

来源：

BLOOD | 2018年 / 132卷 / 15期

基金：

美国国家卫生研究院;

关键词：

HEMATOPOIETIC STEM-CELLS; MESENCHYMAL STROMAL CELLS; TOLL-LIKE RECEPTOR-4; NF-KAPPA-B; ACUTE MYELOID-LEUKEMIA; REGULATORY T-CELLS; INNATE IMMUNE; GENE-EXPRESSION; CLONAL HEMATOPOIESIS; THERAPEUTIC APPROACH;

D O I：

10.1182/blood-2018-03-784116

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic innate immune signaling in hematopoietic cells is widely described in myelodysplastic syndromes (MDS), and innate immune pathway activation, predominantly via pattern recognition receptors, increases the risk of developing MDS. An inflammatory component to MDS has been reported for many years, but only recently has evidence supported a more direct role of chronic innate immune signaling and associated inflammatory pathways in the pathogenesis of MDS. Here we review recent findings and discuss relevant questions related to chronic immune response dysregulation in MDS.

引用

页码：1553 / 1560

页数：8

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