Autophagic programmed cell death in Drosophila

被引:189
作者
Baehrecke, EH [1 ]
机构
[1] Univ Maryland, Maryland Biotechnol Inst, Ctr Biosyst Res, College Pk, MD 20742 USA
关键词
autophagy; apoptosis; proteolysis; cytoplasmic degradation; Drosophila;
D O I
10.1038/sj.cdd.4401280
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Autophagic programmed cell death occurs during the development of diverse animal groups, but the mechanisms that control this genetically regulated form of cell killing are poorly understood. Genetic studies of bulk protein degradation in yeast have provided important advances in our understanding of autophagy, and recent investigations of Drosophila autophagic cell death suggest that some of these mechanisms may be conserved. In Drosophila, several steroid-regulated genes that encode transcription regulators are required for autophagic cell death. These transcription regulators appear to activate a large number of genes that play a more direct role in cell killing, including genes that function in apoptosis such as caspases. While caspase function is required for autophagic cell death during Drosophila development, genes encoding proteins that are similar to the yeast autophagy regulators are also induced in dying salivary glands. Furthermore, numerous noncaspase proteases, cytoplasmic organizing factors, signaling molecules, and unknown factors are expressed in interesting patterns during autophagic cell death. This article reviews the current knowledge of the regulation of autophagic programmed cell death during development of Drosophila.
引用
收藏
页码:940 / 945
页数:6
相关论文
共 73 条
[1]   HORMONES, PUFFS AND FLIES - THE MOLECULAR CONTROL OF METAMORPHOSIS BY ECDYSONE [J].
ANDRES, AJ ;
THUMMEL, CS .
TRENDS IN GENETICS, 1992, 8 (04) :132-138
[3]   CYTOPLASMIC COMPONENTS IN HEPATIC CELL LYSOSOMES [J].
ASHFORD, TP ;
PORTER, KR .
JOURNAL OF CELL BIOLOGY, 1962, 12 (01) :198-&
[4]   How death shapes life during development [J].
Baehrecke, EH .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (10) :779-787
[6]  
Bodenstein D, 1965, BIOL DROSOPHILA, P275
[7]   The Drosophila βFTZ-F1 orphan nuclear receptor provides competence for stage-specific responses to the steroid hormone ecdysone [J].
Broadus, J ;
McCabe, JR ;
Endrizzi, B ;
Thummel, CS ;
Woodard, CT .
MOLECULAR CELL, 1999, 3 (02) :143-149
[8]   Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy [J].
Bursch, W ;
Ellinger, A ;
Kienzl, H ;
Torok, L ;
Pandey, S ;
Sikorska, M ;
Walker, R ;
Hermann, RS .
CARCINOGENESIS, 1996, 17 (08) :1595-1607
[9]   THE DROSOPHILA 74EF EARLY PUFF CONTAINS E74, A COMPLEX ECDYSONE-INDUCIBLE GENE THAT ENCODES 2 ETS-RELATED PROTEINS [J].
BURTIS, KC ;
THUMMEL, CS ;
JONES, CW ;
KARIM, FD ;
HOGNESS, DS .
CELL, 1990, 61 (01) :85-99
[10]   Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex [J].
Cakouros, D ;
Daish, T ;
Martin, D ;
Baehrecke, EH ;
Kumar, S .
JOURNAL OF CELL BIOLOGY, 2002, 157 (06) :985-995