Synthesis of new 1,3-thiazole derivatives from 2(5)-hydroxyalkyl-1,3-thiazole-5(2)-carbaldehydes

被引：1
作者：
Sinenko, V. O. [1 ]
Slivchuk, S. R. [1 ]
Pil'o, S. G. [1 ]
Raenko, G. F. [2 ]
Brovarets, V. S. [1 ]
机构：
[1] Natl Acad Sci Ukraine, Inst Bioorgan Chem & Petrochem, Ul Murmanskaya 1, UA-02660 Kiev, Ukraine
[2] Natl Acad Sci Ukraine, Litvinenko Inst Phys Organ & Coal Chem, Kiev, Ukraine
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2016年 / 86卷 / 07期
关键词：
1,3-thiazole-2-carbaldehyde; 1,3-thiazole-5-carbaldehyde; hydrazones; N-substituted rhodanines; tetrahydropyrimidines; Biginelli reaction; PROTEASE INHIBITORS; DIHYDROPYRIMIDINE; BLOCKERS;
D O I：
10.1134/S1070363216070100
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reactions of substituted 2-hydroxyalkyl-1,3-thiazole-5-carbaldehydes and 5-hydroxyalkyl-1,3-thiazole-2-carbaldehydes with phenylhydrazine, isoniazid, N-substituted rhodanines were performed as well as Biginelli reaction with acetoacetic ester and urea. As a result, new 1,3-thiazole derivatives were obtained. They are of interest as potential bioactive substances.
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收藏
页码：1597 / 1603
页数：7
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